Childhood trauma and the rs1360780 SNP of FKBP5 gene in psychosis: a replication in two general population samples
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Otros documentos de la autoría: Alemany, Silvia; Moya, Jorge; Ibáñez, Manuel I; Villa Martín, Elena; Mezquita, Laura; Ortet, Generós; Gastó, Cristóbal; Fañanás Saura, Lourdes; Arias, Barbara
Metadatos
Mostrar el registro completo del ítemcomunitat-uji-handle:10234/9
comunitat-uji-handle2:10234/8033
comunitat-uji-handle3:10234/8636
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INVESTIGACIONMetadatos
Título
Childhood trauma and the rs1360780 SNP of FKBP5 gene in psychosis: a replication in two general population samplesAutoría
Fecha de publicación
2016Editor
Cambridge University PressISSN
0033-2917; 1469-8978Tipo de documento
info:eu-repo/semantics/articleVersión de la editorial
http://search.proquest.com/docview/1746627724/fulltextPDF/83177BEF27C7485FPQ/1?a ...Versión
info:eu-repo/semantics/submittedVersionPalabras clave / Materias
Resumen
FKBP5 gene interacts with childhood trauma in the risk for several stress-related psychiatric disorders including subclinical psychosis. The present study examined whether variation at the rs1360780 SNP of FKBP5 gene ... [+]
FKBP5 gene interacts with childhood trauma in the risk for several stress-related psychiatric disorders including subclinical psychosis. The present study examined whether variation at the rs1360780 SNP of FKBP5 gene moderated the association between childhood abuse and psychotic experiences. The discovery sample included 437 individuals and the replication sample included 305, all drawn from the general population. In both samples, a significant gene-environment interaction effect was detected indicating that T allele homozygotes of the FKBP5 gene scored significantly higher on positive PEs after exposure to childhood abuse compared to CC carriers. [-]
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Psychological Medicine (2016), 46, 221–223Derechos de acceso
© Cambridge University Press 2015
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