Coordination behaviour of new open chain and macrocyclic peptidomimetic compounds with copper (ii)
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comunitat-uji-handle2:10234/7053
comunitat-uji-handle3:10234/8639
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INVESTIGACIONMetadata
Title
Coordination behaviour of new open chain and macrocyclic peptidomimetic compounds with copper (ii)Author (s)
Date
2015-08Publisher
Royal Society of ChemistryBibliographic citation
WADHAVANE, Prashant D., et al. Coordination behaviour of new open chain and macrocyclic peptidomimetic compounds with copper (ii). RSC Advances, 2015, vol. 5, no 89, p. 72579-72589.Type
info:eu-repo/semantics/articlePublisher version
http://pubs.rsc.org/en/content/articlehtml/2015/ra/c5ra15852dSubject
Abstract
Two valine-derived bis(amino amides) ligands have been prepared and fully characterized. Both compounds contain additional functionalities that implement their basicity and their water solubility. Besides, compound 1 ... [+]
Two valine-derived bis(amino amides) ligands have been prepared and fully characterized. Both compounds contain additional functionalities that implement their basicity and their water solubility. Besides, compound 1 is an open chain ligand, while 2 is a macrocycle. Their protonation constants as well as their stability constants for the formation of the corresponding Cu2+ complexes have been determined potentiometrically. Important differences are associated to the macrocyclic effect and to the additional functionalities in the spacer. The presence of an additional amine group and/or the inclusion of a carboxylic side chain in this spacer increase the stabilities of the Cu2+complexes, suggesting its participation in the interaction with the metal. Thus, 2 is the first pseudopeptidic cyclophane of this family displaying the ability to form highly stable metal complexes in water. UV-Vis and ESI-MS were used for analyzing the complex species detected in the speciation diagram. [-]
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RSC Advances, 2015, vol. 5, no 89Rights
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