Brain activation by an olfactory stimulus paired with juvenile play in female rats
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Otros documentos de la autoría: Paredes Ramos, Pedro; Bowers, J. M.; McCarthy, M. M.; MIQUEL, MARTA; Manzo, Jorge; Coria Ávila, Genaro A.
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http://dx.doi.org/10.1016/j.physbeh.2014.05.008 |
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Título
Brain activation by an olfactory stimulus paired with juvenile play in female ratsAutoría
Fecha de publicación
2014Editor
ElsevierISSN
0031-9384; 1873-507XTipo de documento
info:eu-repo/semantics/articleVersión de la editorial
http://www.sciencedirect.com/science/article/pii/S0031938414002637#?np=yVersión
info:eu-repo/semantics/publishedVersionPalabras clave / Materias
Resumen
We have previously shown that reward experienced during social play at juvenile age can be paired with artificial
odors, and later in adulthood facilitate olfactory conditioned partner preferences (PP) in female rats. ... [+]
We have previously shown that reward experienced during social play at juvenile age can be paired with artificial
odors, and later in adulthood facilitate olfactory conditioned partner preferences (PP) in female rats. Herein, we
examined the expression of FOS immunoreactivity (FOS-IR) following exposure to the odor paired with juvenile
play (CS+). Starting at day P31 females received daily 30-min periods of social play with lemon-scented (paired
group) or unscented females (unpaired group). At day P42, they were tested for play-PP with two juvenile males,
one bearing the CS+ (lemon) and one bearing a novel odor (almond). Females were ovariectomized, hormoneprimed
and at day P55 tested for sexual-PP between two adult stud males scented with lemon or almond. In both
tests, females from the paired group displayed conditioned PP (play or sexual) toward males bearing the CS+. In
the present experiments females were exposed at day P59 to the CS+ during 60 min and their brains processed
for FOS-IR. One group of female rats (Play + Sex) underwent play-PP and sexual-PP, whereas a second group of
females (Play-only) underwent exclusively play-PP but not sexual-PP. Results showed that in the Play-only experiment
exposure to the CS+ induced more FOS-IR in the medial prefrontal cortex, orbitofrontal cortex, dorsal striatum,
and ventral tegmental area as compared to females from the unpaired group. In the Play + Sex experiment,
more FOS-IR was observed in the piriform cortex, dorsal striatum, lateral septum, nucleus accumbens shell, bed
nucleus of the stria terminalis and medial amygdala as compared to females from the unpaired group. Taken together,
these results indicate mesocorticolimbic brain areas direct the expectation and/or choice of conditioned
partners in female rats. In addition, transferring the meaning of play to sex preference requires different brain
areas. [-]
Publicado en
Physiology & Behavior 133 (2014) 39–44Derechos de acceso
© 2014 Elsevier Inc. All rights reserved.
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