Beyond the basal ganglia: cFOS expression in the cerebellum in response to acute and chronic dopaminergic alterations
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http://dx.doi.org/10.1016/j.neuroscience.2014.02.046 |
Metadatos
Título
Beyond the basal ganglia: cFOS expression in the cerebellum in response to acute and chronic dopaminergic alterationsAutoría
Fecha de publicación
2014Editor
ElsevierISSN
0306-4522; 1873-7544Cita bibliográfica
HERRERA-MEZA, G., et al. Beyond the basal ganglia: cFOS expression in the cerebellum in response to acute and chronic dopaminergic alterations. Neuroscience, 2014, vol. 267, p. 219-231.Tipo de documento
info:eu-repo/semantics/articleVersión de la editorial
http://www.sciencedirect.com/science/article/pii/S0306452214002000Versión
info:eu-repo/semantics/publishedVersionPalabras clave / Materias
Resumen
The suggestion of an anatomical and functional relationship between the basal ganglia and cerebellum is recent. Traditionally, these structures were considered as neuronal circuits working separately to organize and ... [+]
The suggestion of an anatomical and functional relationship between the basal ganglia and cerebellum is recent. Traditionally, these structures were considered as neuronal circuits working separately to organize and control goal-directed movements and cognitive functions. However, several studies in rodents and primates have described an anatomical interaction between cortico-basal and cortico-cerebellar networks. Most importantly, functional changes have been observed in one of these circuits when altering the other one. In this context, we aimed to accomplish an extensive description of cerebellar activation patterns using cFOS expression (cFOS-IR) after acute and chronic manipulation of dopaminergic activity. In the acute study, substantia nigra pars compacta (SNc) activity was stimulated or suppressed by intra cerebral administration of picrotoxin or lidocaine, respectively. In addition, we analyzed cerebellar activity after the induction of a parkinsonism model, the tremulous jaw movements. In this model, tremulous jaw movements were induced in male rats by IP chronic administration of the dopamine antagonist haloperidol (1.5 mg/kg). Acute stimulation of SNc by picrotoxin increased cFOS-IR in the vermis and cerebellar hemispheres. However, lidocaine did not produce an effect. After 14 days of haloperidol treatment, the vermis and cerebellar hemispheres showed an opposite regulation of cFOS expression. Chronic dopaminergic antagonism lessened cFOS expression in the vermis but up-regulated such expression in the cerebellar hemisphere. Overall, the present data indicate a very close functional relationship between the basal ganglia and the cerebellum and they may allow a better understanding of disorders in which there are dopamine alterations. [-]
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Neuroscience, 2014, vol. 267Derechos de acceso
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