Design and Synthesis of Pironetin Analogue/Combretastatin A-4 Hybrids and Evaluation of Their Cytotoxic Activity
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Otros documentos de la autoría: Torijano Gutiérrez, Sandra Adela; Vilanova Gallén, Concepción; Diaz-Oltra, Santiago; Murga, Juan; Falomir, Eva; Carda, Miguel; Marco, J. Alberto
Metadatos
Mostrar el registro completo del ítemcomunitat-uji-handle:10234/9
comunitat-uji-handle2:10234/7053
comunitat-uji-handle3:10234/8639
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INVESTIGACIONMetadatos
Título
Design and Synthesis of Pironetin Analogue/Combretastatin A-4 Hybrids and Evaluation of Their Cytotoxic ActivityAutoría
Fecha de publicación
2014Editor
Wiley Online LibraryISSN
1434-193XTipo de documento
info:eu-repo/semantics/articlePalabras clave / Materias
Resumen
We describe the preparation of a series of hybrid molecules containing a combretastatin A-4 moiety and a pironetin analogue fragment linked by an ester spacer of variable length. The cytotoxic activities of these ... [+]
We describe the preparation of a series of hybrid molecules containing a combretastatin A-4 moiety and a pironetin analogue fragment linked by an ester spacer of variable length. The cytotoxic activities of these compounds have been measured and the relationship between the structure and cytotoxicity is discussed. Some of the tested compounds showed cytotoxicity values of the same order of magnitude as those of the parental molecules, combretastatin A-4 and pironetin, and were less toxic than the latter for normal cells. [-]
Publicado en
European Journal of Organic Chemistry, 2014(11)Derechos de acceso
This is the pre-peer reviewed version of the following article: Torijano‐Gutiérrez, S., Vilanova, C., Díaz‐Oltra, S., Murga, J., Falomir, E., Carda, M., & Marco, J. A. (2014). Design and Synthesis of Pironetin Analogue/Combretastatin A‐4 Hybrids and Evaluation of Their Cytotoxic Activity. European Journal of Organic Chemistry, 2014(11), 2284-2296.
which has been published in final form at [http://onlinelibrary.wiley.com/doi/10.1002/ejoc.201301725/full]
http://rightsstatements.org/vocab/InC/1.0/
info:eu-repo/semantics/openAccess
http://rightsstatements.org/vocab/InC/1.0/
info:eu-repo/semantics/openAccess
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