Cerebellar hallmarks of conditioned preference for cocaine
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Título
Cerebellar hallmarks of conditioned preference for cocaineAutoría
Fecha de publicación
2014Editor
ElsevierISSN
0031-9384; 1873-507XTipo de documento
info:eu-repo/semantics/articleVersión de la editorial
http://www.sciencedirect.com/science/article/pii/S0031938414002352Versión
info:eu-repo/semantics/submittedVersionPalabras clave / Materias
Resumen
Pavlovian conditioning tunes the motivational drive of drug-associated stimuli, fostering the probability of those
environmental stimuli to promote and trigger drug seeking and taking. Interestingly, different areas ... [+]
Pavlovian conditioning tunes the motivational drive of drug-associated stimuli, fostering the probability of those
environmental stimuli to promote and trigger drug seeking and taking. Interestingly, different areas in the cerebellum
are involved in the formation and long-lasting storage of Pavlovian emotional memory. Very recently, we
have shown that conditioned preference for an odour associated with cocaine was directly correlated with cFOS
expression in cells at the dorsal region of the granule cell layer of the cerebellar vermis. The main goal of the
current investigation was to further extend the description of cFOS-IR patterns in cerebellar circuitry after training
mice in a cocaine-odour Pavlovian conditioning procedure, including now the major inputs (the inferior olive
and pontine nuclei) and one of the output nuclei (the medial deep nucleus) of the cerebellum. The results showed
that the cerebellar hallmark of preference towards an odour cue associated to cocaine is an increase in cFOS
expression in the dorsal part of the granule cell layer. cFOS-IR levels expressed in the granule cell layer of mice
that did not show cocaine conditioned preference did not differ from the basal levels. Remarkably, mice subjected
to a random cocaine-odour pairing procedure (the unpaired group) exhibited higher cFOS-IR in the inferior olive,
the pontine nuclei and in the deep medial nucleus. Therefore, our findings suggest that inputs and the output of
cerebellar circuitry are enhanced when contingency between the CS+ and cocaine is lacking. [-]
Publicado en
Physiology & Behavior 132 (2014) 24–35Derechos de acceso
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