N-Acetylcysteine boosts xenobiotic detoxification in shellfish
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Scholar |
Otros documentos de la autoría: Peña Llopis, Samuel; Serrano, Roque; Pitarch, Elena; Beltrán Iturat, Eduardo; Ibáñez, Maria; Hernandez, Felix; Peña, Juan B.
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http://dx.doi.org/10.1016/j.aquatox.2014.05.006 |
Metadatos
Título
N-Acetylcysteine boosts xenobiotic detoxification in shellfishAutoría
Fecha de publicación
2014-09Editor
ElsevierISSN
0166-445XTipo de documento
info:eu-repo/semantics/articleVersión de la editorial
http://www.sciencedirect.com/science/article/pii/S0166445X14001659#Palabras clave / Materias
Resumen
Water pollution represents a threat of increasing importance to human health. Bivalve mollusks are filter-feeding organisms that can accumulate chemical and microbiological contaminants in their tissues from very low ... [+]
Water pollution represents a threat of increasing importance to human health. Bivalve mollusks are filter-feeding organisms that can accumulate chemical and microbiological contaminants in their tissues from very low concentrations in the water or sediments. Consumption of contaminated shellfish is one of the main causes of seafood poisoning. Thus, marine bivalves are normally depurated in sterilized seawater for 48 h to allow the removal of bacteria. However, this depuration time might be insufficient to eliminate chemical contaminants from their tissues. We have developed a novel technology that accelerates up to fourfold the excretion rate of xenobiotics in bivalves by treatment with the antioxidant and glutathione (GSH) pro-drug N-acetylcysteine (NAC) during the depuration period. NAC improved dose-dependently the detoxification of the organophosphate (OP) pesticide fenitrothion in the mussel Mytilus galloprovincialis, diminishing its levels up to nearly a hundred fold compared to conventional depuration, by enhancing the glutathione S-transferase (GST) activity and inducing the GSH anabolism (GSH synthesis and reduction by glutathione reductase). Notably, this induction in GSH anabolism and GST activity was also observed in uncontaminated bivalves treated with NAC. As the GSH pathway is involved in the detoxification of many pollutants and biotoxins from harmful algal blooms, we validated this proof of principle in king scallops (Pecten maximus) that naturally accumulated the amnesic shellfish poisoning (ASP) toxin domoic acid. We illustrate here a method that enhances the elimination of organic contaminants in shellfish, opening new avenues of depuration of marine organisms. [-]
Publicado en
Aquatic Toxicology Vol. 154, 2014Derechos de acceso
Copyright © 2015 Elsevier B.V.
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