Polymorphisms in ABC Transporter Genes and Concentrations of Mercury in Newborns – Evidence from Two Mediterranean Birth Cohorts
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comunitat-uji-handle2:10234/36080
comunitat-uji-handle3:10234/36082
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INVESTIGACIONMetadata
Title
Polymorphisms in ABC Transporter Genes and Concentrations of Mercury in Newborns – Evidence from Two Mediterranean Birth CohortsAuthor (s)
Date
2014Publisher
Public Library of ScienceISSN
1932-6203Bibliographic citation
Llop S, Engström K, Ballester F, Franforte E, Alhamdow A, Pisa F, et al. (2014) Polymorphisms in ABC Transporter Genes and Concentrations of Mercury in Newborns – Evidence from Two Mediterranean Birth Cohorts. PLoS ONE 9(5): e97172. doi:10.1371/journal.pone.0097172Type
info:eu-repo/semantics/articlePublisher version
http://www.plosone.org/article/fetchObject.action?uri=info:doi/10.1371/journal.p ...Version
info:eu-repo/semantics/publishedVersionAbstract
Background: The genetic background may influence methylmercury (MeHg) metabolism and neurotoxicity. ATP binding
cassette (ABC) transporters actively transport various xenobiotics across biological membranes.
Objective: ... [+]
Background: The genetic background may influence methylmercury (MeHg) metabolism and neurotoxicity. ATP binding
cassette (ABC) transporters actively transport various xenobiotics across biological membranes.
Objective: To investigate the role of ABC polymorphisms as modifiers of prenatal exposure to MeHg.
Methods: The study population consisted of participants (n = 1651) in two birth cohorts, one in Italy and Greece (PHIME)
and the other in Spain (INMA). Women were recruited during pregnancy in Italy and Spain, and during the perinatal period
in Greece. Total mercury concentrations were measured in cord blood samples by atomic absorption spectrometry.
Maternal fish intake during pregnancy was determined from questionnaires. Polymorphisms (n = 5) in the ABC genes ABCA1,
ABCB1, ABCC1 and ABCC2 were analysed in both cohorts.
Results: ABCB1 rs2032582, ABCC1 rs11075290, and ABCC2 rs2273697 modified the associations between maternal fish intake
and cord blood mercury concentrations. The overall interaction coefficient between rs2032582 and log2-transformed fish
intake was negative for carriers of GT (b = 20.29, 95%CI 20.47, 20.12) and TT (b = 20.49, 95%CI 20.71, 20.26) versus GG,
meaning that for a doubling in fish intake of the mothers, children with the rs2032582 GG genotype accumulated 35% more
mercury than children with TT. For rs11075290, the interaction coefficient was negative for carriers of TC (b = 20.12, 95%CI
20.33, 0.09), and TT (b = 20.28, 95%CI 20.51, 20.06) versus CC. For rs2273697, the interaction coefficient was positive when
combining GA+AA (b = 0.16, 95%CI 0.01, 0.32) versus GG.
Conclusion: The ABC transporters appear to play a role in accumulation of MeHg during early development [-]
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PLoS ONE, May 2014, Volume 9, Issue 5, e97172Rights
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Except where otherwise noted, this item's license is described as © 2014 Llop et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.