An anti-interleukin-2 receptor drug attenuates thelper 1 lymphocytes-mediated inflammation in an acute model of endotoxin-induced uveitis
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Títol
An anti-interleukin-2 receptor drug attenuates thelper 1 lymphocytes-mediated inflammation in an acute model of endotoxin-induced uveitisAutoria
Data de publicació
2014Editor
Public Library of ScienceISSN
1932-6203Cita bibliogràfica
Mérida S, Sancho-Tello M, Navea A, Almansa I, Muriach M, Bosch-Morell F (2014) An Anti-Interleukin-2 Receptor Drug Attenuates T- Helper 1 Lymphocytes-Mediated Inflammation in an Acute Model of Endotoxin-Induced Uveitis. PLoS ONE 9(3): e90216. doi:10.1371/journal.pone.0090216Tipus de document
info:eu-repo/semantics/articleVersió de l'editorial
http://www.plosone.org/article/fetchObject.action?uri=info:doi/10.1371/journal.p ...Versió
info:eu-repo/semantics/publishedVersionResum
The aim of the present study was to evaluate the anti-inflammatory efficacy of Daclizumab, an anti-interleukin-2 receptor
drug, in an experimental uveitis model upon a subcutaneous injection of lipopolysaccharide ... [+]
The aim of the present study was to evaluate the anti-inflammatory efficacy of Daclizumab, an anti-interleukin-2 receptor
drug, in an experimental uveitis model upon a subcutaneous injection of lipopolysaccharide into Lewis rats, a valuable
model for ocular acute inflammatory processes. The integrity of the blood-aqueous barrier was assessed 24 h after
endotoxin-induced uveitis by evaluating two parameters: cell count and protein concentration in aqueous humors. The
histopathology of all the ocular structures (cornea, lens, sclera, choroid, retina, uvea, and anterior and posterior chambers)
was also considered. Enzyme-linked immunosorbent assays of the aqueous humor samples were performed to quantify the
levels of the different chemokine and cytokine proteins. Similarly, a biochemical analysis of oxidative stress-related markers
was also assessed. The inflammation observed in the anterior chamber of the eyes when Daclizumab was administered with
endotoxin was largely prevented since the aqueous humor protein concentration substantially lowered concomitantly with
a significant reduction in the uveal and vitreous histopathological grading. Th1 lymphocytes-related cytokines, such as
Interleukin-2 and Interferon-c, also significantly reduced with related anti-oxidant systems recovery. Daclizumab treatment
in endotoxin-induced uveitis reduced Th1 lymphocytes-related cytokines, such as Interleukin-2 and Interferon gamma, by
about 60–70% and presented a preventive role in endotoxin-induced oxidative stress. This antioxidant protective effect of
Daclizumab may be related to several of the observed Daclizumab effects in our study, including IL-6 cytokine regulatory
properties and a substantial concomitant drop in INFc. Concurrently, Daclizumab treatment triggered a significant
reduction in both the uveal histopathological grading and protein concentration in aqueous humors, but not in cellular
infiltration. [-]
Publicat a
PLOS ONE, March 2014, Volume 9, Issue 3, e90216Drets d'accés
info:eu-repo/semantics/openAccess
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Except where otherwise noted, this item's license is described as © 2014 Mérida et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.