Synthesis of compounds with potential biomedical activity: SARS-CoV-2 main protease inhibitors and ABA analogs
Metadatos
Mostrar el registro completo del ítemcomunitat-uji-handle:10234/9
comunitat-uji-handle2:10234/29747
comunitat-uji-handle3:10234/162741
comunitat-uji-handle4:
TESISMetadatos
Título
Synthesis of compounds with potential biomedical activity: SARS-CoV-2 main protease inhibitors and ABA analogsAutoría
Director/a
González, FlorenciPrograma de Doctorado
Programa de Doctorat en CiènciesÓrgano responsable
Universitat Jaume I. Escola de DoctoratFecha de defensa
2024-04-17Editor
Universitat Jaume IPalabras clave
Área de conocimiento
Páginas
313 p.Resumen
The COVID-19 pandemic, caused by the SARS-CoV-2 virus, has increased the development of new antiviral drugs to stop its spread. This work focused on synthesizing specific inhibitors of the Mpro protease, crucial for ... [+]
The COVID-19 pandemic, caused by the SARS-CoV-2 virus, has increased the development of new antiviral drugs to stop its spread. This work focused on synthesizing specific inhibitors of the Mpro protease, crucial for the virus replication. Compounds with a nitroalkene-type "warhead" were synthesized, showing promising inhibitory activity against this enzyme. Additionally, inhibitors with a keto vinyl sulfone-type "warhead" were synthesized, showing variable inhibition trends against Mpro, CatL, and rhodesain. Furthermore, an ABA antagonist was synthesized, delaying shoot development and fruit generation, offering potential improvements in crop yield. Lastly, fluorescent derivatives of ABA were synthesized, shedding light on its cellular mechanisms. These findings contribute to the development of antiviral drugs and highlight the diverse roles of ABA beyond plants, potentially benefiting human health. [-]
Derechos de acceso
L'accés als continguts d'aquesta tesi queda condicionat a l'acceptació de les condicions d'ús establertes per la següent llicència Creative Commons: http://creativecommons.org/licenses/by-sa/4.0/
info:eu-repo/semantics/embargoedAccess
info:eu-repo/semantics/embargoedAccess