Gray Matter atrophy is associated with functional connectivity reorganization during the Paced Auditory Serial Addition Test (PASAT) execution in Multiple Sclerosis (MS)
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Show full item recordcomunitat-uji-handle:10234/158176
comunitat-uji-handle2:10234/71324
comunitat-uji-handle3:10234/97314
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Title
Gray Matter atrophy is associated with functional connectivity reorganization during the Paced Auditory Serial Addition Test (PASAT) execution in Multiple Sclerosis (MS)Author (s)
Tutor/Supervisor
Forn Frias, Cristina; Universitat Jaume I. Departament de Psicologia Bàsica, Clínica i PsicobiologiaDate
2014-06Abstract
Objective: To explore the relationship between the gray matter (GM) atrophy and functional reorganization in multiple sclerosis (MS) patients during the execution to the Paced Auditory Serial Addition Test (PASAT). ... [+]
Objective: To explore the relationship between the gray matter (GM) atrophy and functional reorganization in multiple sclerosis (MS) patients during the execution to the Paced Auditory Serial Addition Test (PASAT). Methods: Seventeen MS patients and fifteen healthy controls (HC) were selected for the study. Atrophy was explored using a voxel based morphometry (VBM) analysis and connectivity changes related to atrophy were explored using the Psycho-Physiological Interactions (PPI) analysis. Group differences and correlations with PASAT performance and radiological variables were also examined. Results: GM atrophy in MS patients was circumscribed to the bilateral posterior cingulate gyrus (PCG)/precuneus. As compared to HC, MS patients showed stronger connectivity between the left PCG/precuneus and the middle temporal gyrus and left cerebellum. HC showed negative correlation between PASAT scores and connectivity while lower connectivity in all subjects as a whole were correlated with high levels of Brain Parenchymal Fraction (BPF). Conclusions: MS patients in early stages of the disease and low brain damage presented higher connectivity levels during the execution to the PASAT, as interpreted as neuroplasticity processes that helps to preserve the cognitive functions. [-]
Subject
Description
Treball Fi de Grau corresponent a la titulació de Psicologia. Codi: PS1048. Curs 2013-2014
Type
info:eu-repo/semantics/bachelorThesisRights
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info:eu-repo/semantics/restrictedAccess
This item appears in the folowing collection(s)
- Grau en Psicologia [1080]