Isotope pattern deconvolution-tandem mass spectrometry for the determination and confirmation of diclofenac in wastewaters
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Altres documents de l'autoria: Castillo Tirado, Ángel; GRACIA LOR, EMMA; Roig-Navarro, Antoni F.; Sancho, Juan V; Rodríguez González, Pablo; García Alonso, J. Ignacio
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Títol
Isotope pattern deconvolution-tandem mass spectrometry for the determination and confirmation of diclofenac in wastewatersAutoria
Data de publicació
2013-02-26Editor
ElsevierCita bibliogràfica
CASTILLO TIRADO, A.; GRACIA LOR, E.; ROIG NAVARRO, A. F.; SANCHO LLOPIS, J. V.; RODRÍGUEZ GONZÁLEZ, P.; GARCÍA ALONSO, J. I. Isotope pattern deconvolution-tandem mass spectrometry for the determination and confirmation of diclofenac in wastewaters. Analytica Chimica Acta, v. 765 (2013), p. 77– 85Tipus de document
info:eu-repo/semantics/articleVersió de l'editorial
http://ac.els-cdn.com/S0003267012017096/1-s2.0-S0003267012017096-main.pdf?_tid=4 ...Paraules clau / Matèries
Resum
Isotope dilution mass spectrometry (IDMS) based on isotope pattern deconvolution (IPD) has been applied here to MS/MS (QqQ) in order to carry out the quantification and confirmation of organic compounds in complex ... [+]
Isotope dilution mass spectrometry (IDMS) based on isotope pattern deconvolution (IPD) has been applied here to MS/MS (QqQ) in order to carry out the quantification and confirmation of organic compounds in complex matrix water samples without the use of a methodological IDMS calibration graph. In this alternative approach, the isotope composition of the spiked sample is measured after fragmentation by SRM and deconvoluted into its constituting components (molar fractions of natural abundance and labeled compound) by multiple linear regression (IPD). The procedure has been evaluated for the determination of the pharmaceutical diclofenac in effluent and influent urban wastewaters and fortified surface waters by UHPLC (ESI) MS/MS using diclofenac-d4 as labeled compound. Calculations were performed acquiring a part and the whole fragment cluster ion, achieving in all cases recoveries within 90–110% and coefficients of variation below 5% for all water samples tested. In addition, potential false negatives
arising from the presence of diclofenac-d2 impurities in the labeled compound were avoided when the proposed approach was used instead of the most usual IDMS calibration procedure. The number of SRM transitions measured was minimized to three to make possible the application of this alternative technique in routine multi-residue analysis. [-]
Publicat a
Analytica Chimica Acta, n. 765 (2013)Drets d'accés
http://rightsstatements.org/vocab/CNE/1.0/
info:eu-repo/semantics/restrictedAccess
info:eu-repo/semantics/restrictedAccess
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