Abstinence duration modulates striatal functioning during monetary reward processing in cocaine patients
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Altres documents de l'autoria: Bustamante, Juan Carlos; Barrós-Loscertales, Alfonso; Costumero, Víctor; Fuentes-Claramonte, Paola; Rosell Negre, Patricia; Ventura Campos, Mercedes; Llopis Llácer, Juan José; Avila, Cesar
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Títol
Abstinence duration modulates striatal functioning during monetary reward processing in cocaine patientsAutoria
Data de publicació
2013Editor
WileyCita bibliogràfica
BUSTAMANTE, J. C.; BARRÓS LOSCERTALES, A. R.; COSTUMERO RAMOS, V.; FUENTES CLARAMONTE, P.; ROSELL NEGRE, P.; VENTURA CAMPOS, N.; LLOPIS LLÁCER, J. J.; ÁVILA RIVERA, C. Abstinence duration modulates striatal functioning during monetary reward processing in cocaine patients. Addiction Biology, v. 19, issue 5 (September 2014), pp. 885-894Tipus de document
info:eu-repo/semantics/articleVersió de l'editorial
http://onlinelibrary.wiley.com/doi/10.1111/adb.12041/abstractVersió
info:eu-repo/semantics/publishedVersionResum
Pre-clinical and clinical studies in cocaine addiction highlight alterations in the striatal dopaminergic reward system
that subserve maintenance of cocaine use. Using an instrumental conditioning paradigm with ... [+]
Pre-clinical and clinical studies in cocaine addiction highlight alterations in the striatal dopaminergic reward system
that subserve maintenance of cocaine use. Using an instrumental conditioning paradigm with monetary reinforcement,
we studied striatal functional alterations in long-term abstinent cocaine-dependent patients and striatal functioning
as a function of abstinence and treatment duration. Eighteen patients and 20 controls underwent functional
magnetic resonance imaging during a Monetary Incentive Delay task. Region of interest analyses based on masks of
the dorsal and ventral striatum were conducted to test between-group differences and the functional effects in the
cocaine group of time (in months) with no more than two lapses from the first time patients visited the clinical service
to seek treatment at the scanning time (duration of treatment), and the functional effects of the number of months
with no lapses or relapses at the scanning session time (length of abstinence). We applied a voxel-wise and a clusterwise
FWE-corrected level (pFWE) at a threshold of P < 0.05. The patient group showed lower activation in the right
caudate during reward anticipation than the control group. The regression analyses in the patients group revealed a
positive correlation between duration of treatment and brain activity in the left caudate during reward anticipation.
Likewise, length of abstinence negatively correlated with brain activity in the bilateral nucleus accumbens during
monetary outcome processing. In conclusion, caudate and nucleus accumbens showa different brain response pattern
to non-drug rewards during cocaine addiction, which can be modulated by treatment success. [-]
Publicat a
Addiction Biology, v. 19, Issue 5 (September 2014)Drets d'accés
http://rightsstatements.org/vocab/CNE/1.0/
info:eu-repo/semantics/restrictedAccess
info:eu-repo/semantics/restrictedAccess
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