Modulation of ethanol-induced conditioned place preference in mice by 3-amino-1,2,4-triazole and D-penicillamine depends on ethanol dose and number of conditioning trials
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Otros documentos de la autoría: Ledesma Llorente, Juan Carlos; Font Hurtado, Laura; Baliño, Pablo; González Aragón, Carlos Manuel
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http://dx.doi.org/10.1007/s00213-013-3177-7 |
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Título
Modulation of ethanol-induced conditioned place preference in mice by 3-amino-1,2,4-triazole and D-penicillamine depends on ethanol dose and number of conditioning trialsAutoría
Fecha de publicación
2013Editor
SpringerISSN
0033-3158; 1432-2072Cita bibliográfica
LEDESMA, Juan Carlos, et al. Modulation of ethanol-induced conditioned place preference in mice by 3-amino-1, 2, 4-triazole and D-penicillamine depends on ethanol dose and number of conditioning trials. Psychopharmacology, 2013, vol. 230, no 4, p. 557-568Tipo de documento
info:eu-repo/semantics/articleVersión de la editorial
http://download.springer.com/static/pdf/612/art%253A10.1007%252Fs00213-013-3177- ...Versión
info:eu-repo/semantics/publishedVersionPalabras clave / Materias
Resumen
Previous studies have shown that both 3-amino-1,2,4-triazole (AT), which inhibits metabolism of ethanol (EtOH) to acetaldehyde by inhibiting catalase, and D-penicillamine (D-P), an acetaldehyde-sequestering agent, ... [+]
Previous studies have shown that both 3-amino-1,2,4-triazole (AT), which inhibits metabolism of ethanol (EtOH) to acetaldehyde by inhibiting catalase, and D-penicillamine (D-P), an acetaldehyde-sequestering agent, modulate EtOH-conditioned place preference (CPP) in male albino Swiss (IOPS Orl) mice. These studies followed a reference-dose-like procedure, which involves comparing cues that have both been paired with EtOH. However, the role of EtOH-derived acetaldehyde has not been examined using a standard CPP method, and efficacy of these treatments could be different under the two circumstances. In the present investigation, we manipulated the strength of CPP across five separate studies and evaluated the effect of D-P and AT on EtOH-induced CPP following a standard unbiased CPP procedure. Mice received pairings with vehicle-saline injections with one cue and, alternatively, with AT- and D-P-EtOH with another cue. Our studies indicate that AT and D-P only disrupt CPP induced by EtOH in mice when the number of conditioning sessions and the dose of EtOH are low. These findings suggest that acquisition of EtOH-induced CPP may depend on the levels of acetaldehyde available during memory acquisition and the strength of the memory. Therefore, we propose that, at least when the memory processes are labile, brain acetaldehyde could participate in the formation of Pavlovian learning elicited by EtOH. [-]
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Psychopharmacology (2013) vol. 230, no. 4Derechos de acceso
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