Chemoenzymatic synthesis of optically active 2-(2- or 4-substituted-1H-imidazol-1-yl)cycloalcanols. Chiral additives for (L)-proline
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Other documents of the author: Porcar Garcia, Raul; Ríos-Lombardía, Nicolás; Busto, Eduardo; Gotor Fernández, Vicente; Gotor Fernández, Vicente; Garcia-Verdugo, Eduardo; Burguete, M. Isabel; Luis, Santiago V.
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comunitat-uji-handle3:10234/8639
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Title
Chemoenzymatic synthesis of optically active 2-(2- or 4-substituted-1H-imidazol-1-yl)cycloalcanols. Chiral additives for (L)-prolineAuthor (s)
Date
2013-04-03Publisher
Royal Society of ChemistryISSN
2044-4753Bibliographic citation
PORCAR, Raul, et al. Chemoenzymatic synthesis of optically active 2-(2′-or 4′-substituted-1 H-imidazol-1-yl) cycloalkanols: chiral additives for (l)-proline. Catalysis Science & Technology, 2013, vol. 3, no 10, p. 2596-2601Type
info:eu-repo/semantics/articleSubject
Abstract
Enantiopure substituted imidazoles obtained by enzymatic kinetic resolution can be promising candidates as co-catalysts for aldol reactions catalysed by (L)-proline. These additives seem to form supramolecular complexes ... [+]
Enantiopure substituted imidazoles obtained by enzymatic kinetic resolution can be promising candidates as co-catalysts for aldol reactions catalysed by (L)-proline. These additives seem to form supramolecular complexes with the catalyst through the formation of H-bonds, leading to significant improvement in both the reaction rates and selectivity of the reaction. Herein, we present our results on the use of these substituted trans-2-imidazoyl-cycloalkanols as additives for the (L)-proline catalyzed direct aldol reaction between ketones and aromatic aldehydes. [-]
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Catalysis Science & Technology, 2013, vol. 3, no 10Rights
© Royal Society of Chemistry 2014
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