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Automated identification of brain tumors from single MR images based on segmentation with refined patient-specific priors
dc.contributor.author | Sanjuán Tomás, Ana | |
dc.contributor.author | Price, Cathy J. | |
dc.contributor.author | Mancini, Laura | |
dc.contributor.author | Josse, Goulven | |
dc.contributor.author | Grogan, Alice | |
dc.contributor.author | Yamamoto, Adam K. | |
dc.contributor.author | Geva, Sharon | |
dc.contributor.author | Leff, Alex P. | |
dc.contributor.author | Yousry, Tarek A. | |
dc.contributor.author | Seghier, Mohamed L. | |
dc.date.accessioned | 2014-03-14T14:40:26Z | |
dc.date.available | 2014-03-14T14:40:26Z | |
dc.date.issued | 2013 | |
dc.identifier.citation | Sanjuán A, Price CJ, Mancini L, Josse G, Grogan A, Yamamoto AK, Geva S, Leff AP, Yousry TA and Seghier ML (2013) Automated identification of brain tumors from single MR images based on segmentation with refined patient-specific priors. Front. Neurosci. 7:241. doi: 10.3389/fnins.2013.00241 | ca_CA |
dc.identifier.issn | 1662-4548 | |
dc.identifier.issn | 1662-453X | |
dc.identifier.uri | http://hdl.handle.net/10234/87391 | |
dc.description.abstract | Brain tumors can have different shapes or locations, making their identification very challenging. In functional MRI, it is not unusual that patients have only one anatomical image due to time and financial constraints. Here, we provide a modified automatic lesion identification (ALI) procedure which enables brain tumor identification from single MR images. Our method rests on (A) a modified segmentation-normalization procedure with an explicit “extra prior” for the tumor and (B) an outlier detection procedure for abnormal voxel (i.e., tumor) classification. To minimize tissue misclassification, the segmentation-normalization procedure requires prior information of the tumor location and extent. We therefore propose that ALI is run iteratively so that the output of Step B is used as a patient-specific prior in Step A. We test this procedure on real T1-weighted images from 18 patients, and the results were validated in comparison to two independent observers' manual tracings. The automated procedure identified the tumors successfully with an excellent agreement with the manual segmentation (area under the ROC curve = 0.97 ± 0.03). The proposed procedure increases the flexibility and robustness of the ALI tool and will be particularly useful for lesion-behavior mapping studies, or when lesion identification and/or spatial normalization are problematic. | ca_CA |
dc.format.extent | 12 p. | ca_CA |
dc.format.mimetype | application/pdf | ca_CA |
dc.language.iso | eng | ca_CA |
dc.publisher | Frontiers | ca_CA |
dc.relation.isPartOf | Frontiers in Neuroscience, 2013, vol. 7, no 241 | ca_CA |
dc.rights | Copyright © 2013 Sanjuán, Price, Mancini, Josse, Grogan, Yamamoto, Geva, Leff, Yousry and Seghier. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. This Document is Protected by copyright and was first published by Frontiers. All rights reserved. it is reproduced with permission. | ca_CA |
dc.rights | Attribution 4.0 Spain | * |
dc.rights.uri | http://creativecommons.org/licenses/by-sa/4.0/ | * |
dc.subject | Automatic lesion identification | ca_CA |
dc.subject | Segmentation | ca_CA |
dc.subject | Spatial normalization | ca_CA |
dc.subject | Fuzzy clustering | ca_CA |
dc.subject | MRI | ca_CA |
dc.title | Automated identification of brain tumors from single MR images based on segmentation with refined patient-specific priors | ca_CA |
dc.type | info:eu-repo/semantics/article | ca_CA |
dc.identifier.doi | http://dx.doi.org/10.3389/fnins.2013.00241#sthash.C3enYQTi.dpuf | |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | ca_CA |
dc.relation.publisherVersion | http://journal.frontiersin.org/Journal/10.3389/fnins.2013.00241/abstract | ca_CA |
dc.type.version | info:eu-repo/semantics/publishedVersion | ca_CA |
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Except where otherwise noted, this item's license is described as Copyright © 2013 Sanjuán, Price, Mancini, Josse, Grogan, Yamamoto, Geva, Leff, Yousry and Seghier. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. This Document is Protected by copyright and was first published by Frontiers. All rights reserved. it is reproduced with permission.