Electrical pumping of potassium ions against an external concentration gradient in a biological ion channel
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Other documents of the author: Aguilella, Vicente; Alcaraz, Antonio; Ramírez, Patricio; García Giménez, Elena; Mafe, Salvador; Queralt-Martín, María
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Show full item recordcomunitat-uji-handle:10234/9
comunitat-uji-handle2:10234/2507
comunitat-uji-handle3:10234/6973
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Title
Electrical pumping of potassium ions against an external concentration gradient in a biological ion channelAuthor (s)
Date
2013-07-22Publisher
AIP PublishingBibliographic citation
Applied Physics Letters, v. 103, issue 4 (2013, Jul 22), p. 043707-1 -- 043707-4Type
info:eu-repo/semantics/articlePublisher version
http://scitation.aip.org/content/aip/journal/apl/103/4/10.1063/1.4816748Version
info:eu-repo/semantics/publishedVersionSubject
Abstract
We show experimentally and theoretically that significant currents can be obtained with a biological ion channel, the OmpF porin of Escherichia coli, using zero-average potentials as driving forces. The channel ... [+]
We show experimentally and theoretically that significant currents can be obtained with a biological ion channel, the OmpF porin of Escherichia coli, using zero-average potentials as driving forces. The channel rectifying properties can be used to pump potassium ions against an external concentration gradient under asymmetric pH conditions. The results are discussed in terms of the ionic selectivity and rectification ratio of the channel. The physical concepts involved may be applied to separation processes with synthetic nanopores and to bioelectrical phenomena [-]
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