Reward sensitivity modulates connectivity among reward brain areas during processing of anticipatory reward cues
View/ Open
Impact
Scholar |
Other documents of the author: Costumero, Víctor; Barrós-Loscertales, Alfonso; Bustamante, Juan Carlos; Ventura Campos, Mercedes; Fuentes-Claramonte, Paola; Avila, Cesar
Metadata
Show full item recordcomunitat-uji-handle:10234/9
comunitat-uji-handle2:10234/8033
comunitat-uji-handle3:10234/8636
comunitat-uji-handle4:
INVESTIGACIONMetadata
Title
Reward sensitivity modulates connectivity among reward brain areas during processing of anticipatory reward cuesAuthor (s)
Date
2013Publisher
Taylor & FrancisISSN
1359-432X; 1464-0643Bibliographic citation
Eur J Neurosci. 2013 Aug;38(3):2399-407Type
info:eu-repo/semantics/articlePublisher version
The definitive version is available at www3.interscience.wiley.comVersion
info:eu-repo/semantics/submittedVersionSubject
Abstract
Reward sensitivity, or the tendency to engage in motivated approach behavior in the presence of rewarding stimuli, may be a contributory factor for vulnerability to disinhibitory behaviors. Although evidence exists ... [+]
Reward sensitivity, or the tendency to engage in motivated approach behavior in the presence of rewarding stimuli, may be a contributory factor for vulnerability to disinhibitory behaviors. Although evidence exists for a reward sensitivity-related increased response in reward brain areas (i.e. nucleus accumbens or midbrain) during the processing of reward cues, it is unknown how this trait modulates brain connectivity, specifically the crucial coupling between the nucleus accumbens, the midbrain, and other reward-related brain areas, including the medial orbitofrontal cortex and the amygdala. Here, we analysed the relationship between effective connectivity and personality in response to anticipatory reward cues. Forty-four males performed an adaptation of the Monetary Incentive Delay Task and completed the Sensitivity to Reward scale. The results showed the modulation of reward sensitivity on both activity and functional connectivity (psychophysiological interaction) during the processing of incentive cues. Sensitivity to reward scores related to stronger activation in the nucleus accumbens and midbrain during the processing of reward cues. Psychophysiological interaction analyses revealed that midbrain-medial orbitofrontal cortex connectivity was negatively correlated with sensitivity to reward scores for high as compared with low incentive cues. Also, nucleus accumbens-amygdala connectivity correlated negatively with sensitivity to reward scores during reward anticipation. Our results suggest that high reward sensitivity-related activation in reward brain areas may result from associated modulatory effects of other brain regions within the reward circuitry. [-]
Is part of
European Journal of Neuroscience, 2013, vol. 38, no 3Rights
http://rightsstatements.org/vocab/CNE/1.0/
info:eu-repo/semantics/openAccess
info:eu-repo/semantics/openAccess
This item appears in the folowing collection(s)
- PSB_Articles [1293]