Reward sensitivity modulates connectivity among reward brain areas during processing of anticipatory reward cues
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Altres documents de l'autoria: Costumero, Víctor; Barrós-Loscertales, Alfonso; Bustamante, Juan Carlos; Ventura Campos, Mercedes; Fuentes-Claramonte, Paola; Avila, Cesar
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Mostra el registre complet de l'elementcomunitat-uji-handle:10234/9
comunitat-uji-handle2:10234/8033
comunitat-uji-handle3:10234/8636
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Títol
Reward sensitivity modulates connectivity among reward brain areas during processing of anticipatory reward cuesAutoria
Data de publicació
2013Editor
Taylor & FrancisISSN
1359-432X; 1464-0643Cita bibliogràfica
Eur J Neurosci. 2013 Aug;38(3):2399-407Tipus de document
info:eu-repo/semantics/articleVersió de l'editorial
The definitive version is available at www3.interscience.wiley.comVersió
info:eu-repo/semantics/submittedVersionParaules clau / Matèries
Resum
Reward sensitivity, or the tendency to engage in motivated approach behavior in the presence of rewarding stimuli, may be a contributory factor for vulnerability to disinhibitory behaviors. Although evidence exists ... [+]
Reward sensitivity, or the tendency to engage in motivated approach behavior in the presence of rewarding stimuli, may be a contributory factor for vulnerability to disinhibitory behaviors. Although evidence exists for a reward sensitivity-related increased response in reward brain areas (i.e. nucleus accumbens or midbrain) during the processing of reward cues, it is unknown how this trait modulates brain connectivity, specifically the crucial coupling between the nucleus accumbens, the midbrain, and other reward-related brain areas, including the medial orbitofrontal cortex and the amygdala. Here, we analysed the relationship between effective connectivity and personality in response to anticipatory reward cues. Forty-four males performed an adaptation of the Monetary Incentive Delay Task and completed the Sensitivity to Reward scale. The results showed the modulation of reward sensitivity on both activity and functional connectivity (psychophysiological interaction) during the processing of incentive cues. Sensitivity to reward scores related to stronger activation in the nucleus accumbens and midbrain during the processing of reward cues. Psychophysiological interaction analyses revealed that midbrain-medial orbitofrontal cortex connectivity was negatively correlated with sensitivity to reward scores for high as compared with low incentive cues. Also, nucleus accumbens-amygdala connectivity correlated negatively with sensitivity to reward scores during reward anticipation. Our results suggest that high reward sensitivity-related activation in reward brain areas may result from associated modulatory effects of other brain regions within the reward circuitry. [-]
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European Journal of Neuroscience, 2013, vol. 38, no 3Drets d'accés
http://rightsstatements.org/vocab/CNE/1.0/
info:eu-repo/semantics/openAccess
info:eu-repo/semantics/openAccess
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