The mysterious motivational functions of mesolimbic dopamine
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http://dx.doi.org/10.1016/j.neuron.2012.10.021 |
Metadatos
Título
The mysterious motivational functions of mesolimbic dopamineFecha de publicación
2012-11Editor
Cell Press; ElsevierISSN
0896-6273Cita bibliográfica
Neuron ( 2012 Nov 8), 76 ,3, p. 470-85.Tipo de documento
info:eu-repo/semantics/articleVersión de la editorial
http://www.sciencedirect.com/science/article/pii/S0896627312009415Palabras clave / Materias
Resumen
Nucleus accumbens dopamine is known to play a role in motivational processes, and dysfunctions of mesolimbic dopamine may contribute to motivational symptoms of depression and other disorders, as well as features of ... [+]
Nucleus accumbens dopamine is known to play a role in motivational processes, and dysfunctions of mesolimbic dopamine may contribute to motivational symptoms of depression and other disorders, as well as features of substance abuse. Although it has become traditional to label dopamine neurons as "reward" neurons, this is an overgeneralization, and it is important to distinguish between aspects of motivation that are differentially affected by dopaminergic manipulations. For example, accumbens dopamine does not mediate primary food motivation or appetite, but is involved in appetitive and aversive motivational processes including behavioral activation, exertion of effort, approach behavior, sustained task engagement, Pavlovian processes, and instrumental learning. In this review, we discuss the complex roles of dopamine in behavioral functions related to motivation. [-]
Derechos de acceso
Copyright 2012 Elsevier Inc.
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