The mysterious motivational functions of mesolimbic dopamine
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http://dx.doi.org/10.1016/j.neuron.2012.10.021 |
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Title
The mysterious motivational functions of mesolimbic dopamineDate
2012-11Publisher
Cell Press; ElsevierISSN
0896-6273Bibliographic citation
Neuron ( 2012 Nov 8), 76 ,3, p. 470-85.Type
info:eu-repo/semantics/articlePublisher version
http://www.sciencedirect.com/science/article/pii/S0896627312009415Subject
Abstract
Nucleus accumbens dopamine is known to play a role in motivational processes, and dysfunctions of mesolimbic dopamine may contribute to motivational symptoms of depression and other disorders, as well as features of ... [+]
Nucleus accumbens dopamine is known to play a role in motivational processes, and dysfunctions of mesolimbic dopamine may contribute to motivational symptoms of depression and other disorders, as well as features of substance abuse. Although it has become traditional to label dopamine neurons as "reward" neurons, this is an overgeneralization, and it is important to distinguish between aspects of motivation that are differentially affected by dopaminergic manipulations. For example, accumbens dopamine does not mediate primary food motivation or appetite, but is involved in appetitive and aversive motivational processes including behavioral activation, exertion of effort, approach behavior, sustained task engagement, Pavlovian processes, and instrumental learning. In this review, we discuss the complex roles of dopamine in behavioral functions related to motivation. [-]
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Copyright 2012 Elsevier Inc.
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- PSB_Articles [1329]