ROCK/Cdc42-mediated microglial motility and gliapse formation lead to phagocytosis of degenerating dopaminergic neurons in vivo
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Otros documentos de la autoría: Barcia, Carlos; Ros Gómez, Carmen María; Annese, Valentina; Carrillo-de Sauvage, María Ángeles; Ros Bernal, Francisco; Gómez, Aurora; Yuste Jiménez, José Enrique; Campuzano Brando, Carmen María; De Pablos, Vicente; Fernández Villalba, Emiliano; Herrero Ezquerro, María Trinidad
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Título
ROCK/Cdc42-mediated microglial motility and gliapse formation lead to phagocytosis of degenerating dopaminergic neurons in vivoAutoría
Fecha de publicación
2012Editor
Nature Publishing GroupISSN
2045-2322Tipo de documento
info:eu-repo/semantics/articleVersión de la editorial
http://www.readcube.com/articles/10.1038/srep00809?locale=enVersión
info:eu-repo/semantics/publishedVersionPalabras clave / Materias
Resumen
The role of microglial motility in the context of adult neurodegeneration is poorly understood. In the
present work, we investigated the microanatomical details of microglia-neuron interactions in an
experimental ... [+]
The role of microglial motility in the context of adult neurodegeneration is poorly understood. In the
present work, we investigated the microanatomical details of microglia-neuron interactions in an
experimental mouse model of Parkinson’s disease following the intraperitoneal injection of MPTP. The
specific intoxication of dopaminergic neurons induces the cellular polarization of microglia, leading to the
formation of body-to-body neuron-glia contacts, called gliapses, which precede neuron elimination.
Inhibiting ROCK/Cdc42-mediated microglial motility in vivo blocks the activating features of microglia,
such as increased cell size and number of filopodia and diminishes their phagocyting/secreting domains, as
the reduction of the Golgi apparatus and the number of microglia-neuron contacts has shown.
High-resolution confocal images and three-dimensional rendering demonstrate that microglia engulf entire
neurons at one-to-one ratio, and the microglial cell body participates in the formation of the phagocytic cup,
engulfing and eliminating neurons in areas of dopaminergic degeneration in adult mammals. [-]
Publicado en
Scientific Reports, 2012, Vol. 2, Num. 809Derechos de acceso
http://rightsstatements.org/vocab/CNE/1.0/
info:eu-repo/semantics/openAccess
info:eu-repo/semantics/openAccess
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