Nigral degeneration correlates with persistent activation of cerebellar Purkinje cells in MPTP-treated monkeys
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INVESTIGACIONMetadatos
Título
Nigral degeneration correlates with persistent activation of cerebellar Purkinje cells in MPTP-treated monkeysAutoría
Fecha de publicación
2012Editor
Universidad de MurciaISSN
0213-3911; 1699-5848Cita bibliográfica
Histol Histopathol (2012) 27: 89-94Tipo de documento
info:eu-repo/semantics/articleVersión de la editorial
http://www.hh.um.es/2012/HH_27_1_2012.htmVersión
info:eu-repo/semantics/publishedVersionPalabras clave / Materias
Resumen
In the present work we analyze the
cerebellum of chronic parkinsonian monkeys in order to
clarify whether chronic mesencephalic depletion is
associated with long term activation of the cerebellar
neurons in chronic ... [+]
In the present work we analyze the
cerebellum of chronic parkinsonian monkeys in order to
clarify whether chronic mesencephalic depletion is
associated with long term activation of the cerebellar
neurons in chronic Parkinsonism. In our study, we
observed a persistent activation of Purkinje cells in the
cerebellum of chronic parkinsonian macaques,
characterized by the expression of c-Fos, which
correlated with dopaminergic degeneration. These
results are compatible with the results observed in fMRI
in Parkinson’s disease patients, and may contribute to
the understanding of additional alterations in the brain
circuitry in Parkinsonism. [-]
Publicado en
Histology and Histopathology, 2012, Num. 27Derechos de acceso
http://rightsstatements.org/vocab/CNE/1.0/
info:eu-repo/semantics/openAccess
info:eu-repo/semantics/openAccess
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- MED_Articles [639]