Acquisition and reconditioning of ethanol-induced conditioned place preference in mice is blocked by the H2O2 scavenger alpha lipoic acid
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Altres documents de l'autoria: Ledesma Llorente, Juan Carlos; González Aragón, Carlos Manuel
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http://dx.doi.org/10.1007/s00213-012-2831-9 |
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Títol
Acquisition and reconditioning of ethanol-induced conditioned place preference in mice is blocked by the H2O2 scavenger alpha lipoic acidData de publicació
2012Editor
SpringerISSN
0033-3158; 1432-2072Tipus de document
info:eu-repo/semantics/articleVersió de l'editorial
http://link.springer.com/content/pdf/10.1007%2Fs00213-012-2831-9.pdfVersió
info:eu-repo/semantics/publishedVersionParaules clau / Matèries
Resum
Rationale Hydrogen peroxide (H2
O2) is the co-substrate
used by catalase to metabolize ethanol to acetaldehyde in
the brain. This centrally formed acetaldehyde has been
involved in several ethanol-related behavi ... [+]
Rationale Hydrogen peroxide (H2
O2) is the co-substrate
used by catalase to metabolize ethanol to acetaldehyde in
the brain. This centrally formed acetaldehyde has been
involved in several ethanol-related behaviors.
Objectives The present research evaluated the effect of the
H2
O2
scavenger, alpha lipoic acid (LA), on the acquisition
and reconditioning of ethanol-induced conditioned place
preference (CPP).
Methods Mice received pairings of a distinctive floor stimulus (CS+) associated with intraperitoneal injections of ethanol (2.5 g/kg). On alternate days, animals received pairings
of a different floor stimulus (CS−) associated with saline
injections. A different group of animals received pairings
with the (CS−) associated with saline injections, and on
alternate days they received LA (100 mg/kg) injected
30 min prior to ethanol (2.5 g/kg) administration paired with
the (CS+). A preference test assessed the effect of LA on the
acquisition of ethanol-induced CPP. A similar procedure
was followed to study the effect of LA on the acquisition
of cocaine- and morphine-induced CPP. A separate experiment evaluated the effect of LA on the reconditioning of
ethanol-induced CPP. In addition, we investigated the consequence of LA administration on central H2
O2 levels.
Results LA selectively blocked the acquisition of ethanolinduced CPP. Moreover, this compound impaired the reconditioning of ethanol-induced CPP. Additionally, we found
that LA diminished H2
O2 levels in the brain.
Conclusions These data suggest that a decline in H2
O2
availability by LA might impede the formation of brain
ethanol-derived acetaldehyde by catalase, which results in
an impairment of the rewarding properties of ethanol. [-]
Publicat a
Psychopharmacology (2013) 226Drets d'accés
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