Dopaminergic modulation of effort-related choice behavior as assessed by a progressive ratio chow feeding choice task: pharmacological studies and the role of individual differences
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Dopaminergic modulation of effort-related choice behavior as assessed by a progressive ratio chow feeding choice task: pharmacological studies and the role of individual differencesAutoría
Fecha de publicación
2012Editor
Public Library of ScienceISSN
1932-6203; 1932-6203Tipo de documento
info:eu-repo/semantics/articleVersión de la editorial
http://www.plosone.org/article/fetchObject.action?uri=info%3Adoi%2F10.1371%2Fjou ...Versión
info:eu-repo/semantics/publishedVersionResumen
Mesolimbic dopamine (DA) is involved in behavioral activation and effort-related processes. Rats with impaired DA
transmission reallocate their instrumental behavior away from food-reinforced tasks with high response ... [+]
Mesolimbic dopamine (DA) is involved in behavioral activation and effort-related processes. Rats with impaired DA
transmission reallocate their instrumental behavior away from food-reinforced tasks with high response requirements, and
instead select less effortful food-seeking behaviors. In the present study, the effects of several drug treatments were
assessed using a progressive ratio (PROG)/chow feeding concurrent choice task. With this task, rats can lever press on a
PROG schedule reinforced by a preferred high-carbohydrate food pellet, or alternatively approach and consume the lesspreferred
but concurrently available laboratory chow. Rats pass through each ratio level 15 times, after which the ratio
requirement is incremented by one additional response. The DA D2 antagonist haloperidol (0.025–0.1 mg/kg) reduced
number of lever presses and highest ratio achieved but did not reduce chow intake. In contrast, the adenosine A2A
antagonist MSX-3 increased lever presses and highest ratio achieved, but decreased chow consumption. The cannabinoid
CB1 inverse agonist and putative appetite suppressant AM251 decreased lever presses, highest ratio achieved, and chow
intake; this effect was similar to that produced by pre-feeding. Furthermore, DA-related signal transduction activity
(pDARPP-32(Thr34) expression) was greater in nucleus accumbens core of high responders (rats with high lever pressing
output) compared to low responders. Thus, the effects of DA antagonism differed greatly from those produced by prefeeding
or reduced CB1 transmission, and it appears unlikely that haloperidol reduces PROG responding because of a
general reduction in primary food motivation or the unconditioned reinforcing properties of food. Furthermore, accumbens
core signal transduction activity is related to individual differences in work output [-]
Publicado en
PLoS ONE, October, Volume 7, Issue 10, e47934Derechos de acceso
info:eu-repo/semantics/openAccess
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