Post-retrieval propranolol treatment does not modulate reconsolidation or extinction of ethanol-induced conditioned place preference
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Título
Post-retrieval propranolol treatment does not modulate reconsolidation or extinction of ethanol-induced conditioned place preferenceFecha de publicación
2012Editor
ElsevierTipo de documento
info:eu-repo/semantics/articleVersión de la editorial
http://ac.els-cdn.com/S009130571200010X/1-s2.0-S009130571200010X-main.pdf?_tid=d ...Versión
info:eu-repo/semantics/submittedVersionPalabras clave / Materias
Resumen
The reconsolidation hypothesis posits that established emotional memories, when
reactivated, become labile and susceptible to disruption. Post-retrieval injection of propranolol
(PRO), a nonspecific ß-adrenergic ... [+]
The reconsolidation hypothesis posits that established emotional memories, when
reactivated, become labile and susceptible to disruption. Post-retrieval injection of propranolol
(PRO), a nonspecific ß-adrenergic receptor antagonist, impairs subsequent retention performance
of a cocaine- and a morphine-induced conditioned place preference (CPP), implicating the
noradrenergic system in the reconsolidation processes of drug-seeking behavior. An important
question is whether post-retrieval PRO disrupts memory for the drug-cue associations, or instead
interferes with extinction. In the present study, we evaluated the role of the ß-adrenergic system
on the reconsolidation and extinction of ethanol-induced CPP. Male DBA/2J mice were trained
using a weak or a strong conditioning procedure, achieved by varying the ethanol conditioning
dose (1 or 2 g/kg) and the number of ethanol trials (2 or 4). After acquisition of ethanol CPP,
animals were given a single post-retrieval injection of PRO (0, 10 or 30 mg/kg) and tested for
memory reconsolidation 24 h later. Also, after the first reconsolidation test, mice received 18
additional 15-min choice extinction tests in which PRO was injected immediately after every
test. Contrary to the prediction of the reconsolidation hypothesis, a single PRO injection after the
retrieval test did not modify subsequent memory retention. In addition, repeated post-retrieval
administration of PRO did not interfere with extinction of CPP in mice. Overall, our data suggest
that the ß-adrenergic receptor does not modulate the associative processes underlying ethanol
CPP. [-]
Publicado en
Pharmacology Biochemistry and Behavior, Volume 101, Issue 2, April 2012Derechos de acceso
http://rightsstatements.org/vocab/CNE/1.0/
info:eu-repo/semantics/openAccess
info:eu-repo/semantics/openAccess
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