| dc.contributor.author | Diaz-Oltra, Santiago | |
| dc.contributor.author | Angulo-Pachón, César A. | |
| dc.contributor.author | Murga, Juan | |
| dc.contributor.author | Carda, Miguel | |
| dc.contributor.author | Marco, J. Alberto | |
| dc.date.accessioned | 2012-11-22T20:14:26Z | |
| dc.date.available | 2012-11-22T20:14:26Z | |
| dc.date.issued | 2010 | |
| dc.identifier.citation | Journal of Organic Chemistry ( 2010) 75, 5, p. 1775–1778 | ca_CA |
| dc.identifier.issn | 0022-3263 | |
| dc.identifier.uri | http://hdl.handle.net/10234/52356 | |
| dc.description.abstract | A stereoselective synthesis of the cytotoxic 14-membered macrolide aspergillide A has been performed. The preparation of a cis-2,6-disubstituted tetrahydropyran ring via stereoselective reduction of an intermediate cyclic hemiacetal was one key feature of the synthesis. The macrocyclic lactone ring was created by means of a ring-closing metathesis (RCM), whereby the new C═C bond displayed exclusively the undesired Z configuration. Conversion to the required E configuration was achieved via photochemical isomerization. | ca_CA |
| dc.format.extent | 3 p. | ca_CA |
| dc.language.iso | eng | ca_CA |
| dc.publisher | American Chemical Society | ca_CA |
| dc.rights | Copyright © 2010 American Chemical Society | ca_CA |
| dc.rights.uri | http://rightsstatements.org/vocab/InC/1.0/ | * |
| dc.title | Stereoselective Synthesis of the Cytotoxic 14-Membered Macrolide Aspergillide A | ca_CA |
| dc.type | info:eu-repo/semantics/article | ca_CA |
| dc.identifier.doi | http://dx.doi.org/10.1021/jo9027038 | |
| dc.rights.accessRights | info:eu-repo/semantics/restrictedAccess | ca_CA |
| dc.relation.publisherVersion | http://pubs.acs.org/doi/abs/10.1021%2Fjo9027038 | ca_CA |
