Stereoselective Synthesis of the Cytotoxic 14-Membered Macrolide Aspergillide A
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Scholar |
Otros documentos de la autoría: Diaz-Oltra, Santiago; Angulo-Pachón, César A.; Murga, Juan; Carda, Miguel; Marco, J. Alberto
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http://dx.doi.org/10.1021/jo9027038 |
Metadatos
Título
Stereoselective Synthesis of the Cytotoxic 14-Membered Macrolide Aspergillide AAutoría
Fecha de publicación
2010Editor
American Chemical SocietyISSN
0022-3263Cita bibliográfica
Journal of Organic Chemistry ( 2010) 75, 5, p. 1775–1778Tipo de documento
info:eu-repo/semantics/articleVersión de la editorial
http://pubs.acs.org/doi/abs/10.1021%2Fjo9027038Resumen
A stereoselective synthesis of the cytotoxic 14-membered macrolide aspergillide A has been performed. The preparation of a cis-2,6-disubstituted tetrahydropyran ring via stereoselective reduction of an intermediate ... [+]
A stereoselective synthesis of the cytotoxic 14-membered macrolide aspergillide A has been performed. The preparation of a cis-2,6-disubstituted tetrahydropyran ring via stereoselective reduction of an intermediate cyclic hemiacetal was one key feature of the synthesis. The macrocyclic lactone ring was created by means of a ring-closing metathesis (RCM), whereby the new C═C bond displayed exclusively the undesired Z configuration. Conversion to the required E configuration was achieved via photochemical isomerization. [-]
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