Design and synthesis of pironetin analogues with simplified structure and study of their interactions with microtubules
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Other documents of the author: Marco, J. Alberto; García Pla, Jorge; Carda, Miguel; Murga, Juan; Falomir, Eva; Trigili, Chiara; Notararigo, Sara; Díaz, J. Fernando; Barasoain, Isabel
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comunitat-uji-handle2:10234/7053
comunitat-uji-handle3:10234/8639
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http://dx.doi.org/10.1016/j.ejmech.2011.02.011 |
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Title
Design and synthesis of pironetin analogues with simplified structure and study of their interactions with microtubulesAuthor (s)
Date
2011-05Publisher
ElsevierType
info:eu-repo/semantics/articleSubject
Abstract
The preparation of a series of pironetin analogues with simplified structure is described. Their cytotoxic activity and their interactions with tubulin have been investigated. It has been found that, while less active ... [+]
The preparation of a series of pironetin analogues with simplified structure is described. Their cytotoxic activity and their interactions with tubulin have been investigated. It has been found that, while less active than the parent molecule, the pironetin analogues still share the mechanism of action of the latter and compete for the same binding site to α-tubulin. Variations in the configurations of their stereocenters do not translate into relevant differences between biological activities [-]
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European Journal of Medicinal ChemistryRights
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info:eu-repo/semantics/restrictedAccess
info:eu-repo/semantics/restrictedAccess
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- QUIO_Articles [690]