Ratiometric fluorescence sensing of phenylalanine derivatives by synthetic macrocyclic receptors
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Altres documents de l'autoria: Burguete, M. Isabel; Galindo, Francisco; Luis, Santiago V.; Vigara, Laura
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Mostra el registre complet de l'elementcomunitat-uji-handle:10234/9
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comunitat-uji-handle3:10234/8639
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http://dx.doi.org/10.1016/j.jphotochem.2009.10.010 |
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Títol
Ratiometric fluorescence sensing of phenylalanine derivatives by synthetic macrocyclic receptorsData de publicació
2010Editor
ElsevierISSN
10106030Cita bibliogràfica
Journal of Photochemistry and Photobiology A: Chemistry, 209, 1, p. 61-67Tipus de document
info:eu-repo/semantics/articleParaules clau / Matèries
Resum
The supramolecular analytical behavior of eight pseudopeptidic fluorescent receptors (1a-c, 2a-c, 3, 4) has been studied. The receptors are either macrocyclic or open chain derivatives based on the naphthalene chrom ... [+]
The supramolecular analytical behavior of eight pseudopeptidic fluorescent receptors (1a-c, 2a-c, 3, 4) has been studied. The receptors are either macrocyclic or open chain derivatives based on the naphthalene chromophore. The ability of 1-4 for the molecular recognition of amino acids (as Z-protected derivatives) has been evaluated in dichloromethane. The signal observed corresponds to a fluorescence emission of turn-on type. The preferential binding of all the receptors for phenylalanine (Phe) over aliphatic amino acids (Ala, Val) by a factor of 3-4 has been found. Among the family of studied fluorescent molecules, two macrocyclic receptors (1a and 1b) display high exciplex emissions and great fluorescence changes both at long (fluorescence quenching at 390 nm) and short wavelengths (fluorescence enhancement at 340 nm). This feature makes the macrocycles 1a and 1b potentially practical as fluorescent ratiometric sensors for Phe. As a proof of concept, 1a and 1b have been assayed as analytical tools for the identification of model samples enriched with Phe, mimicking the concentrations found in the pathology phenylketonuria (PKU). This result opens the door to the development of new Phe-sensing sensors based on the exciplex signaling mechanism as a new strategy for the analysis of aminoacidemias. © 2009 Elsevier B.V. All rights reserved. [-]
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