Screening of antibiotics in surface and wastewater samples by ultra-high-pressure liquid chromatography coupled to hybrid quadrupole time-of-flight mass spectrometry
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Scholar |
Altres documents de l'autoria: Ibáñez, Maria; Guerrero, Carlos; Sancho, Juan V; Hernandez, Felix
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Mostra el registre complet de l'elementcomunitat-uji-handle:10234/9
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comunitat-uji-handle3:10234/8638
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http://dx.doi.org/10.1016/j.chroma.2009.01.073 |
Metadades
Títol
Screening of antibiotics in surface and wastewater samples by ultra-high-pressure liquid chromatography coupled to hybrid quadrupole time-of-flight mass spectrometryData de publicació
2009Editor
ElsevierISSN
219673Cita bibliogràfica
Journal of Chromatography A, 1216, 12, p. 2529-2539Tipus de document
info:eu-repo/semantics/articleVersió
info:eu-repo/semantics/publishedVersionParaules clau / Matèries
Resum
The potential of ultra-high-pressure liquid chromatography (UHPLC) coupled to hybrid quadrupole time-of-flight mass spectrometry (QTOF-MS) for the screening and confirmation of antibiotics in water samples is illustrated ... [+]
The potential of ultra-high-pressure liquid chromatography (UHPLC) coupled to hybrid quadrupole time-of-flight mass spectrometry (QTOF-MS) for the screening and confirmation of antibiotics in water samples is illustrated in this paper. UHPLC presents several advantages over conventional liquid chromatography as it generates narrow peaks (increasing peak height and improving sensitivity) and reduces chromatographic runs. Regarding QTOF-MS, its increased mass resolution, high sensitivity in full-spectrum acquisition mode and mass accuracy, in both MS and MS/MS modes, make this technique ideal for the detection and reliable confirmation of organic contaminants in environmental samples. After a solid-phase extraction using Oasis HLB cartridges, UHPLC-QTOF-MS has been applied in this work to several types of water samples (surface water and influent and effluent wastewaters). Several antibiotics were found in the samples, such as ofloxacin, ciprofloxacin, clarythromycin or erythromycin, among others. Moreover, the full spectrum data provided by TOF-MS acquisition has enabled searching for many other pharmaceuticals that could be present in the samples in a "post-target" way. This approach has allowed the detection and confirmation of paracetamol, omeprazole and codeine, among others. UPLC-QTOF-MS has been shown as an attractive and efficient hyphenated technique for the rapid detection and confirmation of pharmaceuticals in water with very little sample handling. © 2009 Elsevier B.V. All rights reserved. [-]
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