Dopamine/adenosine interactions involved in effort-related aspects of food motivation
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http://dx.doi.org/10.1016/j.appet.2009.07.018 |
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Title
Dopamine/adenosine interactions involved in effort-related aspects of food motivationDate
2009Publisher
ElsevierISSN
1956663Bibliographic citation
Appetite, 53, 3, p. 422-425Type
info:eu-repo/semantics/articleVersion
info:eu-repo/semantics/publishedVersionSubject
Abstract
Nucleus accumbens dopamine (DA) is involved in effort-related aspects of food motivation. Accumbens DA depletions reduce the tendency of rats to work for food, and alter effort-related choice, but leave other aspects ... [+]
Nucleus accumbens dopamine (DA) is involved in effort-related aspects of food motivation. Accumbens DA depletions reduce the tendency of rats to work for food, and alter effort-related choice, but leave other aspects of food motivation and appetite intact. DA and adenosine receptors interact to regulate effort-related processes. Adenosine A<sub>2A</sub> antagonists can reverse the effects of DA D<sub>2</sub> antagonists on effort-related choice, and intra-accumbens injections of a adenosine A<sub>2A</sub> agonist produce effects that are similar to those produced by accumbens DA depletion or antagonism. These studies have implications for understanding the neurochemical interactions that underlie activational aspects of motivation. © 2009 Elsevier Ltd. All rights reserved. [-]
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