Dopamine/adenosine interactions related to locomotion and tremor in animal models: Possible relevance to parkinsonism
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Scholar |
Altres documents de l'autoria: Salamone, John; Ishiwari, K.; Betz, Adrienne J.; Farrar, Andrew M.; Mingote, Susana; Font Hurtado, Laura; Hockemeyer, J.; Müller, Christa E.; Correa, Merce
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http://dx.doi.org/10.1016/j.parkreldis.2008.04.017 |
Metadades
Títol
Dopamine/adenosine interactions related to locomotion and tremor in animal models: Possible relevance to parkinsonismAutoria
Data de publicació
2008Editor
ElsevierISSN
13538020Cita bibliogràfica
Parkinsonism and Related Disorders, 14, SUPPL.2Tipus de document
info:eu-repo/semantics/articleVersió
info:eu-repo/semantics/submittedVersionParaules clau / Matèries
Resum
Adenosine A<sub>2A</sub> antagonists can exert antiparkinsonian effects in animal models. Recent experiments studied the ability of MSX-3 (an adenosine A<sub>2A</sub> antagonist) to reverse the locomotor suppression ... [+]
Adenosine A<sub>2A</sub> antagonists can exert antiparkinsonian effects in animal models. Recent experiments studied the ability of MSX-3 (an adenosine A<sub>2A</sub> antagonist) to reverse the locomotor suppression and tremor produced by dopamine antagonists in rats. MSX-3 reversed haloperidol-induced suppression of locomotion, and reduced the tremulous jaw movements induced by haloperidol, pimozide, and reserpine. Infusions of MSX-3 into the nucleus accumbens core increased locomotion in haloperidol-treated rats, but there were no effects of infusions into the accumbens shell or ventrolateral neostriatum. In contrast, MSX-3 injected into the ventrolateral neostriatum reduced pimozide-induced tremulous jaw movements. Dopamine/adenosine interactions in different striatal subregions are involved in distinct aspects of motor function. © 2008 Elsevier Ltd. All rights reserved. [-]
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