Inhibition of cAMP responsive element binding protein in striatal neurons enhances approach and avoidance responses toward morphine- and morphine withdrawal-related cues
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Other documents of the author: Sanchis-Segura, Carla; Jancic, Dragana; Jiménez Minchán, María; Barco, Ángel
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comunitat-uji-handle2:10234/8033
comunitat-uji-handle3:10234/8636
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Title
Inhibition of cAMP responsive element binding protein in striatal neurons enhances approach and avoidance responses toward morphine- and morphine withdrawal-related cuesDate
2009Publisher
Frontiers Research FoundationISSN
1662-5153Bibliographic citation
Sanchis-Segura C, Jancic D, Jimenez-Minchan M and Barco A (2009). Inhibition of cAMP responsive element binding protein in striatal neurons enhances approach and avoidance responses toward morphine- and morphine withdrawal-related cues. Front. Behav. Neurosci. 3:30.Type
info:eu-repo/semantics/articleVersion
info:eu-repo/semantics/publishedVersionAbstract
To investigate the role of cAMP responsive element binding protein (CREB)-dependent gene expression in morphine induced behaviors, we examined bitransgenic mice expressing a dominant and strong inhibitor of the CREB ... [+]
To investigate the role of cAMP responsive element binding protein (CREB)-dependent gene expression in morphine induced behaviors, we examined bitransgenic mice expressing a dominant and strong inhibitor of the CREB family of transcription factors, A-CREB, in striatal neurons in a regulatable manner. The expression of A-CREB in the striatum enhanced both morphine-induced conditioned place preference and morphine withdrawal-induced conditioned place avoidance. Our experiments thereby support a role for CREB in striatal neurons regulating approach and avoidance responses toward drug-related cues. [-]
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Frontiers in behavioral neuroscience, vol. 3 (Sept. 2009)Rights
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