Singlet oxygen generation using a porous monolithic polymer supported photosensitizer: potential application to the photodynamic destruction of melanoma cells
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Otros documentos de la autoría: Burguete, M. Isabel; Galindo, Francisco; Gavara, Raquel; Luis, Santiago V.; Moreno, Miguel; Thomas, Paul; Russell, David A.
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Título
Singlet oxygen generation using a porous monolithic polymer supported photosensitizer: potential application to the photodynamic destruction of melanoma cellsAutoría
Fecha de publicación
2009-01Editor
Royal Society of ChemistryISSN
1474-905XCita bibliográfica
BURGUETE, M. Isabel, et al. Singlet oxygen generation using a porous monolithic polymer supported photosensitizer: potential application to the photodynamic destruction of melanoma cells. Photochemical & Photobiological Sciences, 2009, vol. 8, no 1, p. 37-44.Tipo de documento
info:eu-repo/semantics/articleVersión de la editorial
https://pubs.rsc.org/en/content/articlelanding/2009/PP/b810921d#!divAbstractPalabras clave / Materias
Resumen
Photogeneration of singlet oxygen (1O2) by rose bengal is improved through the use of a porous
monolithic polymer (PMP) as a support, as compared to a classic gel-type resin matrix. This type of
monolithic polymeric ... [+]
Photogeneration of singlet oxygen (1O2) by rose bengal is improved through the use of a porous
monolithic polymer (PMP) as a support, as compared to a classic gel-type resin matrix. This type of
monolithic polymeric matrix can be made at a multigram scale in quantitative yields enabling the
preparation of large amounts of supported photosensitizer at low cost. The singlet oxygen induced
oxidation of 9,10-diphenylanthracene has been used as a benchmark reaction, and a comparative study
using rose bengal in solution, entrapped within gel-type derived polymer and entrapped within a
porous monolithic polymer (PMP) has been performed. The enhanced photoreactivity of the
PMP-rose bengal conjugates has been utilised for the successful photodynamic therapy (PDT) of
melanoma cells [-]
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Photochemical and photobiological sciences, 2009, v. 8, n. 1Derechos de acceso
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