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Effect of Hyaluronic Acid on the Self-Assembly of a Dipeptide-Based Supramolecular Gel
dc.contributor.author | Giménez Hernández, Bárbara | |
dc.contributor.author | Falomir, Eva | |
dc.contributor.author | Escuder, Beatriu | |
dc.date.accessioned | 2023-12-22T12:10:12Z | |
dc.date.available | 2023-12-22T12:10:12Z | |
dc.date.issued | 2023-10-02 | |
dc.identifier.citation | GIMÉNEZ‐HERNÁNDEZ, Bárbara; FALOMIR, Eva; ESCUDER, Beatriu. Effect of Hyaluronic Acid on the Self‐Assembly of a Dipeptide‐Based Supramolecular Gel. ChemBioChem, 2023, vol. 24, no 23, p. e202300438. | ca_CA |
dc.identifier.uri | http://hdl.handle.net/10234/205278 | |
dc.description.abstract | The combination of polymers and low molecular weight (LMW) compounds is a powerful approach to prepare new supramolecular materials. Here we prepare two-component hydrogels made by a well-known and biologically active polymer, hyaluronic acid (HA), and a dipeptide-based supramolecular gelator. We undertake a detailed study of materials with different compositions including macroscopic (hydrogel formation, rheology) and micro/nanoscopic characterization (electron microscopy, X-ray powder diffraction). We observe that the two components mutually benefit in the new materials: a minimum amount of HA helps to reduce the polymorphism of the LMW network leading to reproducible hydrogels with improved mechanical properties; the LMW component network holds HA without the need for an irreversible covalent crosslinking. These materials have a great potential for biomedical application as, for instance, extracellular matrix mimetics for cell growth. As a proof of concept, we have observed that this material is effective for cell growth in suspension and avoids cell sedimentation even in the presence of competing cell-adhesive surfaces. This may be of interest to advanced cell delivery techniques. | ca_CA |
dc.description.sponsorShip | Funding for open access charge: CRUE-Universitat Jaume I | |
dc.format.extent | 7 p. | ca_CA |
dc.format.mimetype | application/pdf | ca_CA |
dc.language.iso | eng | ca_CA |
dc.publisher | Wiley | ca_CA |
dc.rights | © 2023 The Authors. ChemBioChem published by Wiley-VCH GmbH. | ca_CA |
dc.rights.uri | http://creativecommons.org/licenses/by-nc/4.0/ | ca_CA |
dc.subject | hydrogels | ca_CA |
dc.subject | peptides | ca_CA |
dc.subject | self-assembly | ca_CA |
dc.subject | supramolecular | ca_CA |
dc.subject | hyaluronic acid | ca_CA |
dc.title | Effect of Hyaluronic Acid on the Self-Assembly of a Dipeptide-Based Supramolecular Gel | ca_CA |
dc.type | info:eu-repo/semantics/article | ca_CA |
dc.identifier.doi | https://doi.org/10.1002/cbic.202300438 | |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | ca_CA |
dc.type.version | info:eu-repo/semantics/publishedVersion | ca_CA |
project.funder.name | MCIN/AEI/10.13039/501100011033 | ca_CA |
project.funder.name | ERDF A way of making Europe | ca_CA |
project.funder.name | Universitat Jaume I | ca_CA |
oaire.awardNumber | PID2019-110892RB-I00 | ca_CA |
oaire.awardNumber | RTC-2017-6465-1 | ca_CA |
oaire.awardNumber | UJI-B2020-21 | ca_CA |
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