Putting forward a model for the role of the cerebellum in cocaine-induced pavlovian memory
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Otros documentos de la autoría: Melchor Eixea, Ignasi; Guarque-Chabrera, Julian; Sánchez Hernández, Aitor; Ibáñez-Marín, Patricia; Pastor Medall, Raúl; MIQUEL, MARTA
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Título
Putting forward a model for the role of the cerebellum in cocaine-induced pavlovian memoryAutoría
Fecha de publicación
2023Editor
Frontiers MediaISSN
1662-5137Cita bibliográfica
Melchor-Eixea I, Guarque-Chabrera J, Sanchez-Hernandez A, Ibáñez-Marín P, Pastor R and Miquel M (2023) Putting forward a model for the role of the cerebellum in cocaine-induced pavlovian memory. Front. Syst. Neurosci. 17:1154014. doi: 10.3389/fnsys.2023.1154014Tipo de documento
info:eu-repo/semantics/articleVersión
info:eu-repo/semantics/publishedVersionPalabras clave / Materias
Resumen
Substance Use Disorder (SUD) involves emotional, cognitive, and motivational
dysfunction. Long-lasting molecular and structural changes in brain regions
functionally and anatomically linked to the cerebellum, such ... [+]
Substance Use Disorder (SUD) involves emotional, cognitive, and motivational
dysfunction. Long-lasting molecular and structural changes in brain regions
functionally and anatomically linked to the cerebellum, such as the prefrontal
cortex, amygdala, hippocampus, basal ganglia, and ventral tegmental area, are
characteristic of SUD. Direct and indirect reciprocal connectivity between the
cerebellum and these brain regions can explain cerebellar roles in Pavlovian and
reinforcement learning, fear memory, and executive functions. It is increasingly
clear that the cerebellum modulates brain functions altered in SUD and other
neuropsychiatric disorders that exhibit comorbidity with SUD. In the present
manuscript, we review and discuss this evidence and present new research
exploring the role of the cerebellum in cocaine-induced conditioned memory
using chemogenetic tools (designer receptor exclusively activated by designer
drug, DREADDs). Our preliminary data showed that inactivation of a region that
includes the interposed and lateral deep cerebellar nuclei reduces the facilitating
effect of a posterior vermis lesion on cocaine-induced preference conditioning.
These findings support our previous research and suggest that posterior vermis
damage may increase drug impact on the addiction circuitry by regulating activity
in the DCN. However, they raise further questions that will also be discussed. [-]
Publicado en
Frontiers in Systems Neuroscience 17:1154014Entidad financiadora
Universitat Jaume I | Ministerio de Sanidad, Consumo y Bienestar Social | Ministerio de Ciencia e Innovación | Ministerio de Economía, Industria y Competitividad | Conselleria d’Innovació, Universitats, Ciència i Societat Digital (PI-M)
Código del proyecto o subvención
UJI-B2020-1 | PND-132400 | PGC2018-095980-B-I00 | MCIN/AEI/10.13039/501100011033 | BES-2016-076353 | ACIF/2019/109 | PRE2019-088521
Derechos de acceso
info:eu-repo/semantics/openAccess
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