Proteomics as a tool to study the osteoimmunomodulatory role of metallic ions in a sol–gel coating
Impacto
Scholar |
Otros documentos de la autoría: García-Arnáez, Iñaki; Romero-Gavilán, Francisco J; Cerqueira, Andreia; Azkargorta, Mikel; Elortza, Félix; Suay, Julio; Goñi, Isabel; Gurruchaga, Mariló
Metadatos
Mostrar el registro completo del ítemcomunitat-uji-handle:10234/9
comunitat-uji-handle2:10234/7034
comunitat-uji-handle3:10234/8619
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INVESTIGACIONMetadatos
Título
Proteomics as a tool to study the osteoimmunomodulatory role of metallic ions in a sol–gel coatingAutoría
Fecha de publicación
2023Editor
Royal Society of ChemistryISSN
2050-750X; 2050-7518Cita bibliográfica
I. García-Arnáez , F. Romero-Gavilán, A. Cerqueira, M. Azkargorta, F. Elortza, J. Suay, I. Goñi and M. Gurruchaga. Proteomics as a tool to study the osteoimmunomodulatory role of metallic ions in a sol-gel coating. J. Mater. Chem. B, 2023,11, 8194-8205. doi: 10.1039/D3TB01204BTipo de documento
info:eu-repo/semantics/articleVersión de la editorial
https://pubs.rsc.org/en/content/articlehtml/2023/tb/d3tb01204bVersión
info:eu-repo/semantics/publishedVersionPalabras clave / Materias
Resumen
The success of bone implants depends on the osteoimmunomodulatory (OIM) activity of the biomaterials in the interactions with the periimplantary tissues. Many in vitro tests have been conducted to evaluate the osteo ... [+]
The success of bone implants depends on the osteoimmunomodulatory (OIM) activity of the biomaterials in the interactions with the periimplantary tissues. Many in vitro tests have been conducted to evaluate the osteoimmunology effects of biomaterials. However, results of these tests have often been inconclusive. This study examines the properties of newly developed sol–gel coatings doped with two metal ions associated with bone regeneration, Ca and Zn. The study uses both proteomic methods and traditional in vitro assays. The results demonstrate that proteomics is an effective tool to scrutinize the OIM properties of the materials. Moreover, sol–gel coatings offer excellent base materials to evaluate the effects of metal ions on these properties. The obtained data highlight the highly tunable nature of sol–gel materials; studying the materials with different doping levels supplies valuable information on the interactions between the immune and bone-forming processes. [-]
Publicado en
Journal of Materials Chemistry B, 2023, vol. 11, no 34Entidad financiadora
Ministerio de Ciencia, Innovación y Universidades | Euskal Herriko Unibertsitatea | Diputación de Gipuzkoa | Universitat Jaume I | Generalitat Valenciana
Identificador de la entidad financiadora
http://dx.doi.org/10.13039/501100011033
Código del proyecto o subvención
MICIU/ICTI2017-2020/PID2020-113092RB-C21 | MARSA21/07 | 2021-CIEN-000072-01 | UJI-B2021-25 | APOSTD/2020/036 | PROMETEO/2020/069
Título del proyecto o subvención
Desarrollo de recubrimientos osteoinductores y obtención de biomarcadores de regeneración ósea
Derechos de acceso
info:eu-repo/semantics/openAccess
Aparece en las colecciones
- ESID_Articles [466]