Mostrar el registro sencillo del ítem
Nucleus incertus projections to rat medial septum and entorhinal cortex: rare collateralization and septal-gating of temporal lobe theta rhythm activity
dc.contributor.author | Gil-Miravet, Isis | |
dc.contributor.author | Nuñez Molina, Angel | |
dc.contributor.author | Navarro Sánchez, Mónica | |
dc.contributor.author | Castillo-Gómez, Esther | |
dc.contributor.author | Ros, Francisco | |
dc.contributor.author | Gundlach, Andrew Lawrence | |
dc.contributor.author | Olucha-Bordonau, Francisco E | |
dc.date.accessioned | 2023-07-20T07:23:28Z | |
dc.date.available | 2023-07-20T07:23:28Z | |
dc.date.issued | 2023 | |
dc.identifier.citation | Gil-Miravet, I., Núñez-Molina, Á., Navarro-Sánchez, M. et al. Nucleus incertus projections to rat medial septum and entorhinal cortex: rare collateralization and septal-gating of temporal lobe theta rhythm activity. Brain Struct Funct 228, 1307–1328 (2023). https://doi.org/10.1007/s00429-023-02650-x | ca_CA |
dc.identifier.issn | 1863-2653 | |
dc.identifier.issn | 1863-2661 | |
dc.identifier.uri | http://hdl.handle.net/10234/203400 | |
dc.description.abstract | Nucleus incertus (NI) neurons in the pontine tegmentum give rise to ascending forebrain projections and express the neuropeptide relaxin-3 (RLN3) which acts via the relaxin-family peptide 3 receptor (RXFP3). Activity in the hippocampus and entorhinal cortex can be driven from the medial septum (MS), and the NI projects to all these centers, where a prominent pattern of activity is theta rhythm, which is related to spatial memory processing. Therefore, we examined the degree of collateralization of NI projections to the MS and the medial temporal lobe (MTL), comprising medial and lateral entorhinal cortex (MEnt, LEnt) and dentate gyrus (DG), and the ability of the MS to drive entorhinal theta in the adult rat. We injected fluorogold and cholera toxin-B into the MS septum and either MEnt, LEnt or DG, to determine the percentage of retrogradely labeled neurons in the NI projecting to both or single targets, and the relative proportion of these neurons that were RLN3-positive ( +). The projection to the MS was threefold stronger than that to the MTL. Moreover, a majority of NI neurons projected independently to either MS or the MTL. However, RLN3 + neurons collateralize significantly more than RLN3-negative (–) neurons. In in vivo studies, electrical stimulation of the NI induced theta activity in the MS and the entorhinal cortex, which was impaired by intraseptal infusion of an RXFP3 antagonist, R3(BΔ23-27)R/I5, particularly at ~ 20 min post-injection. These findings suggest that the MS plays an important relay function in the NI-induced generation of theta within the entorhinal cortex. | ca_CA |
dc.description.sponsorShip | Funding for open access charge: CRUE-Universitat Jaume I | |
dc.format.extent | 22 p. | ca_CA |
dc.format.mimetype | application/pdf | ca_CA |
dc.language.iso | eng | ca_CA |
dc.publisher | Springer | ca_CA |
dc.relation | Desarrollo de sistemas peptidérgicos relacionados con comportamiento social. la interacción relaxin3-oxitocina | ca_CA |
dc.relation | Modulación por IGFI de la plasticidad sináptica en la corteza somestésica del ratón. Alteraciones en modelos de la enfermedad de Alzheimer y en diabetes | ca_CA |
dc.relation.isPartOf | Brain Structure and Function, 2023, vol 228 | ca_CA |
dc.relation.uri | http://hdl.handle.net/10234/201305 | ca_CA |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | ca_CA |
dc.subject | arousal | ca_CA |
dc.subject | emotion | ca_CA |
dc.subject | GABA | ca_CA |
dc.subject | hippocampus | ca_CA |
dc.subject | relaxin-3 | ca_CA |
dc.subject | RXFP3 | ca_CA |
dc.subject | spatial memory | ca_CA |
dc.title | Nucleus incertus projections to rat medial septum and entorhinal cortex: rare collateralization and septal-gating of temporal lobe theta rhythm activity | ca_CA |
dc.type | info:eu-repo/semantics/article | ca_CA |
dc.identifier.doi | https://doi.org/10.1007/s00429-023-02650-x | |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | ca_CA |
dc.relation.publisherVersion | https://link.springer.com/article/10.1007/s00429-023-02650-x | ca_CA |
dc.description.sponsorship | This research was funded by the Postdoctoral Program of the UJI POSDOC/2021/19 (IG-M); UJI Predoctoral Program PREDOC/2021/19 (MN-S); Fundación Alicia Koplowitz, Spain, grant number 19I436 (FEO-B, FR-B, EC-G); the Spanish Ministerio de Ciencia, Innovación y Universidades, grant number RTI2018-095698-B-I00 (FEO-B, IG-M, FR-B, EC-G); AICO Generalitat Valenciana, grant number AICO/2021/246 (EC-G, FO-B, FR-B), National Health and Medical Research Council of Australia, grant number (ALG), the Spanish Ministerio de Ciencia, Innovación y Universidades, grant number PID2019-107809RB-I00 (AN-M) and Universitat Jaume I, grant numbers UJI-A2017-17 (FR-B) and UJI-B2019-54 (FEO-B). | |
dc.description.sponsorship | Open Access funding provided thanks to the CRUE-CSIC agreement with Springer Nature. Funding was provided by the Universitat Jaume I, POSDOC/2021/19, PREDOC/2021/19, UJI-A2017-17, Ministerio de Ciencia, Innovación y Universidades, PID2019-107809RB-I00, RTI2018-095698-B-I00, Fundación Alicia Koplowitz, 19I436, Conselleria de Innovación, Universidades, Ciencia y Sociedad Digital, Generalitat Valenciana, AICO/2021/246, National Health and Medical Research Council of Australia, 1067522. | |
dc.type.version | info:eu-repo/semantics/publishedVersion | ca_CA |
project.funder.identifier | http://dx.doi.org/10.13039/501100011033 | ca_CA |
project.funder.name | Ministerio de Ciencia, Innovación y Universidades | ca_CA |
project.funder.name | Generalitat Valenciana | ca_CA |
project.funder.name | Fundación Alicia Koplowitz | ca_CA |
project.funder.name | National Health and Medical Research Council of Australia | ca_CA |
project.funder.name | Universitat Jaume I | ca_CA |
oaire.awardNumber | MICIU/ICTI2017-2020/RTI2018-095698-B-I00 | ca_CA |
oaire.awardNumber | MICIU/ICTI2017-2020/PID2019-107809RB-I00 | ca_CA |
oaire.awardNumber | AICO/2021/246 | ca_CA |
oaire.awardNumber | 19I436 | ca_CA |
oaire.awardNumber | 1067522 | ca_CA |
oaire.awardNumber | PREDOC/2021/19 | ca_CA |
oaire.awardNumber | POSDOC/2021/19 | ca_CA |
oaire.awardNumber | UJI-A2017-17 | ca_CA |
oaire.awardNumber | UJI-B2019-54 | ca_CA |
dc.subject.ods | 3. Salud y bienestar |
Ficheros en el ítem
Este ítem aparece en la(s) siguiente(s) colección(ones)
-
MED_Articles [649]
Articles de publicacions periòdiques