Neural Stem Cells as Potential Glioblastoma Cells of Origin
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Otros documentos de la autoría: Loras Monfort, Alba; Gonzalez Bonet, Luis Germán; Gutierrez-Arroyo, Julia L.; Martinez-Cadenas, Conrado; Marques-Torrejon, Maria Angeles
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Título
Neural Stem Cells as Potential Glioblastoma Cells of OriginAutoría
Fecha de publicación
2023Editor
MDPICita bibliográfica
Loras, A.; Gonzalez-Bonet, L.G.; Gutierrez-Arroyo, J.L.; Martinez-Cadenas, C.; Marques-Torrejon, M.A. Neural Stem Cells as Potential Glioblastoma Cells of Origin. Life 2023, 13, 905. https:// doi.org/10.3390/life13040905Tipo de documento
info:eu-repo/semantics/articleVersión de la editorial
https://www.mdpi.com/2075-1729/13/4/905Versión
info:eu-repo/semantics/publishedVersionPalabras clave / Materias
Resumen
Glioblastoma multiforme (GBM) is the most malignant brain tumor in adults and it remains
incurable. These tumors are very heterogeneous, resistant to cytotoxic therapies, and they show high
rates of invasiveness. ... [+]
Glioblastoma multiforme (GBM) is the most malignant brain tumor in adults and it remains
incurable. These tumors are very heterogeneous, resistant to cytotoxic therapies, and they show high
rates of invasiveness. Therefore, patients face poor prognosis, and the survival rates remain very
low. Previous research states that GBM contains a cell population with stem cell characteristics called
glioma stem cells (GSCs). These cells are able to self-renew and regenerate the tumor and, therefore,
they are partly responsible for the observed resistance to therapies and tumor recurrence. Recent data
indicate that neural stem cells (NSCs) in the subventricular zone (SVZ) are the cells of origin of GBM,
that is, the cell type acquiring the initial tumorigenic mutation. The involvement of SVZ-NSCs is also
associated with GBM progression and recurrence. Identifying the cellular origin of GBM is important
for the development of early detection techniques and the discovery of early disease markers. In this
review, we analyze the SVZ-NSC population as a potential GBM cell of origin, and its potential role
for GBM therapies. [-]
Publicado en
Life, 2023.Entidad financiadora
"Margarita Salas" postdoctoral contract | 'Maria Zambrano' research contract | European Union-Next generation EU
Código del proyecto o subvención
21-076 | MAZ/2021/03 UP2021-021
Derechos de acceso
info:eu-repo/semantics/openAccess
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