Vitamin D supplementation and Its impact on mortality and cardiovascular outcomes: systematic review and meta-analysis of 80 randomized clinical trials
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INVESTIGACIONMetadatos
Título
Vitamin D supplementation and Its impact on mortality and cardiovascular outcomes: systematic review and meta-analysis of 80 randomized clinical trialsAutoría
Fecha de publicación
2023-04-07Editor
MDPIISSN
2072-6643Cita bibliográfica
Ruiz-García, A.; Pallarés-Carratalá, V.; Turégano-Yedro, M.; Torres, F.; Sapena, V.; Martin-Gorgojo, A.; Martin-Moreno, J.M. Vitamin D Supplementation and Its Impact on Mortality and Cardiovascular Outcomes: Systematic Review and Meta-Analysis of 80 Randomized Clinical Trials. Nutrients 2023, 15, 1810.Tipo de documento
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info:eu-repo/semantics/publishedVersionPalabras clave / Materias
Resumen
Background: The impact of vitamin D supplementation on cardiovascular outcomes and mortality risk reduction remains unclear due to conflicting study findings. Methods: We conducted a systematic review and meta-analysis ... [+]
Background: The impact of vitamin D supplementation on cardiovascular outcomes and mortality risk reduction remains unclear due to conflicting study findings. Methods: We conducted a systematic review and meta-analysis of randomized controlled trials (RCTs), published between 1983 and 2022, that reported the effect of vitamin D supplementation in adults versus placebo or no treatment on all-cause mortality (ACM), cardiovascular mortality (CVM), non-cardiovascular mortality (non-CVM), and cardiovascular morbidities. Only studies with a follow-up period longer than one year were included. The primary outcomes were ACM and CVM. Secondary outcomes were non-CVM, myocardial infarction, stroke, heart failure, and major or extended adverse cardiovascular events. Subgroup analyses were performed according to low-, fair- and good-quality RCTs. Results: Eighty RCTs were assessed, including 82,210 participants receiving vitamin D supplementation and 80,921 receiving placebo or no treatment. The participants’ mean (SD) age was 66.1 (11.2) years, and 68.6% were female. Vitamin D supplementation was associated with a lower risk of ACM (OR: 0.95 [95%CI 0.91–0.99] p = 0.013), was close to statistical significance for a lower risk of non-CVM (OR: 0.94 [95%CI 0.87–1.00] p = 0.055), and was not statistically associated with a lower risk of any cardiovascular morbi-mortality outcome. Meta-analysis of low-quality RCTs showed no association with cardiovascular or non-cardiovascular morbi-mortality outcomes. Conclusions: The emerging results of our meta-analysis present evidence that vitamin D supplementation appears to decrease the risk of ACM (especially convincing in the fair- and good-quality RCTs), while not showing a decrease in the specific cardiovascular morbidity and mortality risk. Thus, we conclude that further research is warranted in this area, with well-planned and executed studies as the basis for more robust recommendations. [-]
Publicado en
Nutrients 2023, Vol. 15 (8)Derechos de acceso
info:eu-repo/semantics/openAccess
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