Relationship of DRD5 and MAO-B VNTR polymorphisms with paranoid and antisocial personality disorders in polydrug users
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Otros documentos de la autoría: O'Higgins, Marcelo; Benito, Ana; Real-López, Matias; Gil-Miravet, Isis; Ochoa, Enrique; Haro Cortés, Gonzalo
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Título
Relationship of DRD5 and MAO-B VNTR polymorphisms with paranoid and antisocial personality disorders in polydrug usersAutoría
Fecha de publicación
2022Editor
WileyCita bibliográfica
O'Higgins, M., Benito, A., Real-Lopez, M., Gil-Miravet, I., Ochoa, E., & Haro, G. (2023). Relationship of DRD5 and MAO-B VNTR polymorphisms with paranoid and antisocial personality disorders in polydrug users. Personality and Mental Health, 17(1), 77–86. https://doi.org/10.1002/pmh.1563Tipo de documento
info:eu-repo/semantics/articleVersión de la editorial
https://onlinelibrary.wiley.com/doi/full/10.1002/pmh.1563Versión
info:eu-repo/semantics/publishedVersionResumen
Although multiple studies have shown the role genetics plays in personality
disorders and in addictions, few have studied the genetic aspects of their
comorbidity. Here, we carried out a cross-sectional study in a ... [+]
Although multiple studies have shown the role genetics plays in personality
disorders and in addictions, few have studied the genetic aspects of their
comorbidity. Here, we carried out a cross-sectional study in a sample comprising 303 Caucasian polydrug-consuming patients. The presence of personality
disorders was evaluated using the International Personality Disorder Examination, and genes related to dopamine, serotonin and monoamine oxidase
(MAO) were genotyped. A significant relationship was observed between the
bp 279 DRD5 variable number of tandem repeat (VNTR) polymorphism and
paranoid personality disorder OR 95 ð Þ ð Þ¼ %CI 2:186 1ð Þ :074;4:449 ;p ¼ 0:006 .
The bp 182 OR 95 ð Þ ð Þ¼ %CI 0:407 0ð Þ :178;0:931 ;p ¼ 0:033 and bp
184 OR 95 ð Þ ð Þ¼ %CI 0:391 0ð Þ :188;0:813 ;p ¼ 0:012 alleles of the MAOB VNTR
were also associated with antisocial personality disorder. Among patients with
addictions, paranoid personality disorder should also be considered in addition
to the importance of antisocial and borderline personality disorders. The higher
frequency of the bp 279 DRD5 VNTR allele found in patients with paranoid personality disorder, as well as the associations between alleles of the MAOB VNTR
and antisocial personality disorder, support the monoaminergic bases of these
personality disorders, especially when dealing with patients with addictions. [-]
Publicado en
Personality and Mental Health, 2023, 17.Entidad financiadora
Fundación de Investigación del Hospital Provincial de Castellón | Generalitat Valenciana
Código del proyecto o subvención
CS2003-05-05 | CAF 15-049, 21-042, 21-043 | T4591000
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© 2022 The Authors Personality and Mental Health Published by John Wiley & Sons Ltd.