Development of a simple and low-cost prototype probe fully-compatible with atmospheric solids analysis probe for the analysis of human breath in real-time
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Otros documentos de la autoría: Fabregat-Safont, David; Ibañez Martinez, Maria; Hernandez, Felix; Sancho, Juan V
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Development of a simple and low-cost prototype probe fully-compatible with atmospheric solids analysis probe for the analysis of human breath in real-timeFecha de publicación
2021-12-16Editor
ElsevierCita bibliográfica
FABREGAT-SAFONT, David, et al. Development of a simple and low-cost prototype probe fully-compatible with atmospheric solids analysis probe for the analysis of human breath in real-time. Microchemical Journal, 2022, vol. 174, p. 107086.Tipo de documento
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info:eu-repo/semantics/submittedVersionPalabras clave / Materias
Resumen
The analysis in real-time of the exhaled breath has gained great attention in the last years due to the high number of possible applications, such as the investigation of endogenous compounds, the detection of disease ... [+]
The analysis in real-time of the exhaled breath has gained great attention in the last years due to the high number of possible applications, such as the investigation of endogenous compounds, the detection of disease biomarkers, or the determination of exogenous compounds related to the consumption of certain products. Although commercial ionization sources are already available for breath analysis, they require an important economic investment and/or complex setups. In this article, we describe a new probe developed at our laboratory, fully compatible with the Waters Corp. atmospheric solids analysis probe (ASAP), and where manufacturing is neither expensive nor complex. This atmospheric breath analysis probe (ABAP) can be directly used in Waters mass spectrometry instruments without the need of modifying the ionization source, the instrument or the ASAP, being also compatible with the software provided by the manufacturer. The ionization of the compounds is based on atmospheric pressure chemical ionization. The prototype has been successfully used in a high-resolution mass spectrometry system, and applied to the analysis of compounds present in human breath, as well as to the tentative identification of different substances present in foods and reported in exhaled breath after food consumption. Additionally, the ABAP has proven its applicability for the analysis in real-time of volatile compounds present in food using a purge-and-trap-like setup. Finally, ABAP could also be compatible with other ionization techniques, such as photoionization. [-]
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Microchemical Journal Vol. 174, March 2022Entidad financiadora
Universitat Jaume I | Generalitat Valenciana | Ministerio de Educación, Cultura y Deporte, Spain
Código del proyecto o subvención
UJI-B2018-19 | Group of Excellence PROMETEO/2019/040 | FPU15/02033
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© 2021 Elsevier B.V. All rights reserved.
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