Glutathione-responsive molecular nanoparticles from a dianionic bolaamphiphile and their use as carriers for targeted delivery
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Scholar |
Otros documentos de la autoría: Navarro Barreda, Diego; Bedrina Broch, Begoña; Galindo, Francisco; Miravet, Juan
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Mostrar el registro completo del ítemcomunitat-uji-handle:10234/9
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https://doi.org/10.1016/j.jcis.2021.10.142 |
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Título
Glutathione-responsive molecular nanoparticles from a dianionic bolaamphiphile and their use as carriers for targeted deliveryFecha de publicación
2021-11-06Editor
ElsevierISSN
0021-9797Cita bibliográfica
Navarro-Barreda, D., Bedrina, B., Galindo, F., & Miravet, J. F. (2022). Glutathione-responsive molecular nanoparticles from a dianionic bolaamphiphile and their use as carriers for targeted delivery. Journal of Colloid and Interface Science, 608, 2009-2017.Tipo de documento
info:eu-repo/semantics/articleVersión
info:eu-repo/semantics/publishedVersionPalabras clave / Materias
Resumen
The formation in aqueous media of molecular nanoparticles from a bolaamphiphile (SucIleCsa) incorporating a disulfide moiety is described. The particles can be loaded efficiently with the lipophilic mitochondrial ... [+]
The formation in aqueous media of molecular nanoparticles from a bolaamphiphile (SucIleCsa) incorporating a disulfide moiety is described. The particles can be loaded efficiently with the lipophilic mitochondrial marker DiOC6(3), quenching its fluorescence, which is recovered upon reductive particle disassembly. DiOC6(3) transport into human colorectal adenocarcinoma cells (HT-29) is demonstrated using flow cytometry and confocal scanning fluorescence microscopy. A significant increase in intracellular fluorescence is observed when the cells are stimulated to produce glutathione (GSH). These new molecular nanoparticles can be considered a theranostic tool that simultaneously achieves targeted delivery of lipophilic substances and signals high levels of GSH. [-]
Publicado en
ournal of Colloid and Interface Science 608 (2022) 2009–2017Datos relacionados
https://ars.els-cdn.com/content/image/1-s2.0-S0021979721018154-mmc1.docxEntidad financiadora
Ministerio de Ciencia, Innovación y Universidades (Spain) | European Regional Development Fund | FISABIO | Generalitat Valenciana | Universitat Jaume I
Código del proyecto o subvención
RTI2018-096748-B-I00 | UGP-19-033 | AICO/2020/322 | UJI-B2018-30
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©2021 Elsevier Inc. All rights reserved.
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info:eu-repo/semantics/restrictedAccess
http://rightsstatements.org/vocab/InC/1.0/
info:eu-repo/semantics/restrictedAccess
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