Impact of Fluoxetine on Behavioral Invigoration of Appetitive and Aversively Motivated Responses: Interaction With Dopamine Depletion
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Otros documentos de la autoría: Carratalá-Ros, Carla; López Cruz, Laura; Martínez Verdú, Andrea; Olivares-García, Régulo; Salamone, John; Correa, Merce
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Título
Impact of Fluoxetine on Behavioral Invigoration of Appetitive and Aversively Motivated Responses: Interaction With Dopamine DepletionAutoría
Fecha de publicación
2021Editor
Frontiers MediaISSN
1662-5153Cita bibliográfica
Carratalá-Ros C, López-Cruz L, Martínez-Verdú A, Olivares-García R, Salamone JD and Correa M (2021) Impact of Fluoxetine on Behavioral Invigoration of Appetitive and Aversively Motivated Responses: Interaction With Dopamine Depletion. Front. Behav. Neurosci. 15:700182. doi: 10.3389/fnbeh.2021.700182Tipo de documento
info:eu-repo/semantics/articleVersión
info:eu-repo/semantics/publishedVersionPalabras clave / Materias
Resumen
Impaired behavioral activation and effort-related motivational dysfunctions like fatigue
and anergia are debilitating treatment-resistant symptoms of depression. Depressed
people show a bias towards the selection ... [+]
Impaired behavioral activation and effort-related motivational dysfunctions like fatigue
and anergia are debilitating treatment-resistant symptoms of depression. Depressed
people show a bias towards the selection of low effort activities. To determine if the
broadly used antidepressant fluoxetine can improve behavioral activation and reverse
dopamine (DA) depletion-induced anergia, male CD1 mice were evaluated for vigorous
escape behaviors in an aversive context (forced swim test, FST), and also with an
exercise preference choice task [running wheel (RW)-T-maze choice task]. In the FST,
fluoxetine increased active behaviors (swimming, climbing) while reducing passive ones
(immobility). However, fluoxetine was not effective at reducing anergia induced by the
DA-depleting agent tetrabenazine, further decreasing vigorous climbing and increasing
immobility. In the T-maze, fluoxetine alone produced the same pattern of effects as
tetrabenazine. Moreover, fluoxetine did not reverse tetrabenazine-induced suppression
of RW time but it reduced sucrose intake duration. This pattern of effects produced
by fluoxetine in DA-depleted mice was dissimilar from devaluing food reinforcement
by pre-feeding or making the food bitter since in both cases sucrose intake time
was reduced but animals compensated by increasing time in the RW. Thus, fluoxetine
improved escape in an aversive context but decreased relative preference for active
reinforcement. Moreover, fluoxetine did not reverse the anergic effects of DA depletion.
These results have implications for the use of fluoxetine for treating motivational
symptoms such as anergia in depressed patients. [-]
Publicado en
Frontiers in Behavioral Neuroscience, 2021, 15: 151Entidad financiadora
Ministerio de Ciencia Investigación y Universidades | Ministerio de Economía y Competitividad | Conselleria d’Innovació, Universitats, Ciència i Societat Digital. GV. | Ministerio de Ciencia, Investigación y Universidades
Código del proyecto o subvención
RTI2018-101424-BI00/AEI/10.13039/501100011033 | NIH/NIMH (R03MH094966-01A1) | FPI BES-2016-077177 | PROMETEO/2020/032 | PRE2019-090163
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Excepto si se señala otra cosa, la licencia del ítem se describe como: © 2021 Carratalá-Ros, López-Cruz, Martínez-Verdú, Olivares-García, Salamone and Correa. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.