The balancing act of NEET proteins: Iron, ROS, calcium and metabolism
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Otros documentos de la autoría: Nechushtai, Rachel; Karmi, Ola; Zuo, Ke; Marjault, Henri-Baptiste; Darash-Yahana, Merav; Sohn, Yang-Sung; King, Skylar D.; I Zandalinas, Sara; Carloni, Paolo; Mittler, Ron
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INVESTIGACIONMetadatos
Título
The balancing act of NEET proteins: Iron, ROS, calcium and metabolismAutoría
Fecha de publicación
2020-11Editor
ElsevierISSN
0167-4889Cita bibliográfica
Nechushtai, R., Karmi, O., Zuo, K., Marjault, H. B., Darash-Yahana, M., Sohn, Y. S., King, S. D., Zandalinas, S. I., Carloni, P., & Mittler, R. (2020). The balancing act of NEET proteins: Iron, ROS, calcium and metabolism. Biochimica et biophysica acta. Molecular cell research, 1867(11), 118805. https://doi.org/10.1016/j.bbamcr.2020.118805Tipo de documento
info:eu-repo/semantics/articleVersión de la editorial
https://www.sciencedirect.com/science/article/pii/S0167488920301634Versión
info:eu-repo/semantics/submittedVersionPalabras clave / Materias
Resumen
NEET proteins belong to a highly conserved group of [2Fe–2S] proteins found across all kingdoms of life. Due to their unique [2Fesingle bond2S] cluster structure, they play a key role in the regulation of many different ... [+]
NEET proteins belong to a highly conserved group of [2Fe–2S] proteins found across all kingdoms of life. Due to their unique [2Fesingle bond2S] cluster structure, they play a key role in the regulation of many different redox and oxidation processes. In eukaryotes, NEET proteins are localized to the mitochondria, endoplasmic reticulum (ER) and the mitochondrial-associated membranes connecting these organelles (MAM), and are involved in the control of multiple processes, ranging from autophagy and apoptosis to ferroptosis, oxidative stress, cell proliferation, redox control and iron and iron‑sulfur homeostasis. Through their different functions and interactions with key proteins such as VDAC and Bcl-2, NEET proteins coordinate different mitochondrial, MAM, ER and cytosolic processes and functions and regulate major signaling molecules such as calcium and reactive oxygen species. Owing to their central role in cells, NEET proteins are associated with numerous human maladies including cancer, metabolic diseases, diabetes, obesity, and neurodegenerative diseases. In recent years, a new and exciting role for NEET proteins was uncovered, i.e., the regulation of mitochondrial dynamics and morphology. This new role places NEET proteins at the forefront of studies into cancer and different metabolic diseases, both associated with the regulation of mitochondrial dynamics. Here we review recent studies focused on the evolution, biological role, and structure of NEET proteins, as well as discuss different studies conducted on NEET proteins function using transgenic organisms. We further discuss the different strategies used in the development of drugs that target NEET proteins, and link these with the different roles of NEET proteins in cells. [-]
Publicado en
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2020, vol. 1867, no 11Entidad financiadora
National Science Foundation | Bond Life Sciences Early Concept Grant | University of Missouri | European Commission
Código del proyecto o subvención
NSF-BSF MCB-1936590 | IOS-1932639 | IOS-1353886 | BSF 2015831 | 765048
Proyecto de investigación
info:eu-repo/grantAgreement/EC/H2020/ 765048/EU/Derechos de acceso
Copyright © Elsevier B.V. All rights reserved.
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info:eu-repo/semantics/openAccess
http://rightsstatements.org/vocab/CNE/1.0/
info:eu-repo/semantics/openAccess
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