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Non-Polymeric Nanogels as Versatile Nanocarriers: Intracellular Transport of the Photosensitizers Rose Bengal and Hypericin for Photodynamic Therapy
dc.contributor.author | Torres-Martínez, Ana | |
dc.contributor.author | Bedrina, Begoña | |
dc.contributor.author | Falomir, Eva | |
dc.contributor.author | Marín, María J. | |
dc.contributor.author | Angulo-Pachón, César A. | |
dc.contributor.author | Galindo, Francisco | |
dc.contributor.author | Miravet, Juan | |
dc.date.accessioned | 2021-06-08T10:07:16Z | |
dc.date.available | 2021-06-08T10:07:16Z | |
dc.date.issued | 2021-04-19 | |
dc.identifier.citation | Torres-Martinez, A., Bedrina, B., Falomir, E., Marin, M. J., Angulo-Pachon, C. A., Galindo, F., & Miravet, J. F. Non-polymeric nanogels as versatile nanocarriers: Intracellular transport of the photosensitizers Rose Bengal and Hypericin for photodynamic therapy. ACS Applied Bio Materials 2021 4 (4), 3658-3669. https://doi.org/10.1021/acsabm.1c00139 | ca_CA |
dc.identifier.issn | 2576-6422 | |
dc.identifier.uri | http://hdl.handle.net/10234/193311 | |
dc.description.abstract | The use of nanocarriers for intracellular transport of actives has been extensively studied in recent years and represents a central area of nanomedicine. The main novelty of this paper lies on the use of nanogels formed by a low-molecular-weight gelator (1). Here, non-polymeric, molecular nanogels are successfully used for intracellular transport of two photodynamic therapy (PDT) agents, Rose Bengal (RB) and hypericin (HYP). The two photosensitizers (PSs) exhibit different drawbacks for their use in clinical applications. HYP is poorly water-soluble, while the cellular uptake of RB is hindered due to its dianionic character at physiological pH values. Additionally, both PSs tend to aggregate precluding an effective PDT. Despite the different nature of these PSs, nanogels from gelator 1 provide, in both cases, an efficient intracellular transport into human colon adenocarcinoma cells (HT-29) and a notably improved PDT efficiency, as assessed by confocal laser scanning microscopy and flow cytometry. Furthermore, no significant dark toxicity of the nanogels is observed, supporting the biocompatibility of the delivery system. The developed nanogels are highly reproducible due to their non-polymeric nature, and their synthesis is easily scaled up. The results presented here thus confirm the potential of molecular nanogels as valuable nanocarriers, capable of entrapping both hydrophobic and hydrophilic actives, for PDT of cancer. | ca_CA |
dc.description.sponsorShip | Funding for open access charge: CRUE-Universitat Jaume I | |
dc.format.extent | 12 p. | ca_CA |
dc.format.mimetype | application/pdf | ca_CA |
dc.language.iso | eng | ca_CA |
dc.publisher | American Chemical Society | ca_CA |
dc.relation.isPartOf | ACS Applied Bio Materials, 2021, vol. 4, no 4 | ca_CA |
dc.rights.uri | http://creativecommons.org/licenses/by-sa/4.0/ | * |
dc.subject | nanogels | ca_CA |
dc.subject | organic molecular nanoparticles | ca_CA |
dc.subject | nanovehicles | ca_CA |
dc.subject | photodynamic therapy | ca_CA |
dc.subject | drug delivery | ca_CA |
dc.subject | nanomedicine | ca_CA |
dc.subject | Rose Bengal | ca_CA |
dc.subject | hypericin | ca_CA |
dc.title | Non-Polymeric Nanogels as Versatile Nanocarriers: Intracellular Transport of the Photosensitizers Rose Bengal and Hypericin for Photodynamic Therapy | ca_CA |
dc.type | info:eu-repo/semantics/article | ca_CA |
dc.identifier.doi | https://doi.org/10.1021/acsabm.1c00139 | |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | ca_CA |
dc.relation.publisherVersion | https://pubs.acs.org/doi/abs/10.1021/acsabm.1c00139 | ca_CA |
dc.description.sponsorship | Ministerio de Economía y Competitividad of Spain (grants CTQ2015-71004-R and RTI2018-101675-B-I00) and Universitat Jaume I (grant UJI-B2018-54) are thanked for financial support. A.T.-M. thanks Ministerio de Educación, Cultura y Deporte of Spain for an FPU fellowship (FPU14/05974). Technical support from SCIC of Universitat Jaume I is acknowledged. | |
dc.type.version | info:eu-repo/semantics/publishedVersion | ca_CA |
project.funder.name | Ministerio de Economía y Competitividad (España) | ca_CA |
project.funder.name | Universitat Jaume I | ca_CA |
project.funder.name | Ministerio de Educación, Cultura y Deporte (España) | ca_CA |
oaire.awardNumber | CTQ2015-71004-R | ca_CA |
oaire.awardNumber | RTI2018-101675-B-I00 | ca_CA |
oaire.awardNumber | UJI-B2018-54 | ca_CA |
oaire.awardNumber | FPU14/05974 | ca_CA |
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