Non-Polymeric Nanogels as Versatile Nanocarriers: Intracellular Transport of the Photosensitizers Rose Bengal and Hypericin for Photodynamic Therapy
Impacto
Scholar |
Otros documentos de la autoría: Torres-Martínez, Ana; Bedrina, Begoña; Falomir, Eva; Marín, María J.; Angulo-Pachón, César A.; Galindo, Francisco; Miravet, Juan
Metadatos
Mostrar el registro completo del ítemcomunitat-uji-handle:10234/9
comunitat-uji-handle2:10234/7053
comunitat-uji-handle3:10234/8639
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INVESTIGACIONMetadatos
Título
Non-Polymeric Nanogels as Versatile Nanocarriers: Intracellular Transport of the Photosensitizers Rose Bengal and Hypericin for Photodynamic TherapyAutoría
Fecha de publicación
2021-04-19Editor
American Chemical SocietyISSN
2576-6422Cita bibliográfica
Torres-Martinez, A., Bedrina, B., Falomir, E., Marin, M. J., Angulo-Pachon, C. A., Galindo, F., & Miravet, J. F. Non-polymeric nanogels as versatile nanocarriers: Intracellular transport of the photosensitizers Rose Bengal and Hypericin for photodynamic therapy. ACS Applied Bio Materials 2021 4 (4), 3658-3669. https://doi.org/10.1021/acsabm.1c00139Tipo de documento
info:eu-repo/semantics/articleVersión de la editorial
https://pubs.acs.org/doi/abs/10.1021/acsabm.1c00139Versión
info:eu-repo/semantics/publishedVersionPalabras clave / Materias
Resumen
The use of nanocarriers for intracellular transport of actives has been extensively studied in recent years and represents a central area of nanomedicine. The main novelty of this paper lies on the use of nanogels ... [+]
The use of nanocarriers for intracellular transport of actives has been extensively studied in recent years and represents a central area of nanomedicine. The main novelty of this paper lies on the use of nanogels formed by a low-molecular-weight gelator (1). Here, non-polymeric, molecular nanogels are successfully used for intracellular transport of two photodynamic therapy (PDT) agents, Rose Bengal (RB) and hypericin (HYP). The two photosensitizers (PSs) exhibit different drawbacks for their use in clinical applications. HYP is poorly water-soluble, while the cellular uptake of RB is hindered due to its dianionic character at physiological pH values. Additionally, both PSs tend to aggregate precluding an effective PDT. Despite the different nature of these PSs, nanogels from gelator 1 provide, in both cases, an efficient intracellular transport into human colon adenocarcinoma cells (HT-29) and a notably improved PDT efficiency, as assessed by confocal laser scanning microscopy and flow cytometry. Furthermore, no significant dark toxicity of the nanogels is observed, supporting the biocompatibility of the delivery system. The developed nanogels are highly reproducible due to their non-polymeric nature, and their synthesis is easily scaled up. The results presented here thus confirm the potential of molecular nanogels as valuable nanocarriers, capable of entrapping both hydrophobic and hydrophilic actives, for PDT of cancer. [-]
Publicado en
ACS Applied Bio Materials, 2021, vol. 4, no 4Entidad financiadora
Ministerio de Economía y Competitividad (España) | Universitat Jaume I | Ministerio de Educación, Cultura y Deporte (España)
Código del proyecto o subvención
CTQ2015-71004-R | RTI2018-101675-B-I00 | UJI-B2018-54 | FPU14/05974
Derechos de acceso
info:eu-repo/semantics/openAccess
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