Biochemical and behavioral consequences of ethanol intake in a mouse model of metabolic syndrome
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INVESTIGACIONMetadatos
Título
Biochemical and behavioral consequences of ethanol intake in a mouse model of metabolic syndromeFecha de publicación
2021-01-15Editor
MDPIISSN
1422-0067Cita bibliográfica
Baliño, P.; Romero-Cano, R.; Muriach, M. Biochemical and Behavioral Consequences of Ethanol Intake in a Mouse Model of Metabolic Syndrome. Int. J. Mol. Sci. 2021, 22, 807. https://doi.org/10.3390/ ijms22020807Tipo de documento
info:eu-repo/semantics/articleVersión de la editorial
https://www.mdpi.com/1422-0067/22/2/807Versión
info:eu-repo/semantics/publishedVersionPalabras clave / Materias
Resumen
Ethanol abuse is a common issue in individuals with sedentary lifestyles, unbalanced diets,
and metabolic syndrome. Both ethanol abuse and metabolic syndrome have negative impacts on
the central nervous system, with ... [+]
Ethanol abuse is a common issue in individuals with sedentary lifestyles, unbalanced diets,
and metabolic syndrome. Both ethanol abuse and metabolic syndrome have negative impacts on
the central nervous system, with effects including cognitive impairment and brain oxidative status
deterioration. The combined effects of ethanol abuse and metabolic syndrome at a central level have
not yet been elucidated in detail. Thus, this work aims to determine the effects of ethanol intake on a
mouse model of metabolic syndrome at the behavioral and biochemical levels. Seven-week-old male
control (B6.V-Lep ob/+JRj) and leptin-deficient (metabolic syndrome) (B6.V-Lep ob/obJRj) mice were
used in the study. Animals were divided into four groups: control, ethanol, obese, and obese–ethanol.
Ethanol consumption was monitored for 6 weeks. Basal glycemia, insulin, and glucose overload
tests were performed. To assess short- and long-term memory, an object recognition test was used.
In order to assess oxidative status in mouse brain samples, antioxidant enzyme activity was analyzed
with regard to glutathione peroxidase, glutathione reductase, glutathione, glutathione disulfide,
lipid peroxidation products, and malondialdehyde. Ethanol intake modulated the insulin response
and impaired the oxidative status in the ob mouse brain. [-]
Publicado en
International Journal of Molecular Sciences. Vol. 22, issue 2, nº 807 (January-2 2021)Entidad financiadora
Universitat Jaume I (UJI)
Código del proyecto o subvención
UJI-A2016-03 | UJI-B2019-38
Derechos de acceso
info:eu-repo/semantics/openAccess
Aparece en las colecciones
- MED_Articles [639]
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