Design, Synthesis and Evaluation of Fluorescent Analogues of Abscisic Acid
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Scholar |
Otros documentos de la autoría: González, Florenci; Bou Iserte, Lledó; Miguel-López, Borja; de la hoz rodriguez, Sergio; Kersten, Christian; Sánchez-Sarasúa, Sandra; Espinosa-Fernández, Verónica; Sánchez-Pérez, Ana María
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https://doi.org/10.1002/slct.202002294 |
Metadatos
Título
Design, Synthesis and Evaluation of Fluorescent Analogues of Abscisic AcidAutoría
Fecha de publicación
2020-07-13Editor
WileyISSN
2365-6549Cita bibliográfica
F. V. González, L. Bou-Iserte, B. Miguel-López, S. de la Hoz-Rodríguez, C. Kersten, S. Sánchez-Sarasúa, V. Espinosa-Fernández, A. M. Sánchez-Pérez, ChemistrySelect 2020, 5, 8015.Tipo de documento
info:eu-repo/semantics/articleVersión de la editorial
https://chemistry-europe.onlinelibrary.wiley.com/doi/full/10.1002/slct.202002294Versión
info:eu-repo/semantics/publishedVersionPalabras clave / Materias
Resumen
A fluorescent analogue of abscisic acid has been prepared by combining (S)‐abscisic acid (ABA) with nitrobenzoxadiazole (NBD) fluorophore using ethanol amine as a linker. Isomerization of the double bond at the side ... [+]
A fluorescent analogue of abscisic acid has been prepared by combining (S)‐abscisic acid (ABA) with nitrobenzoxadiazole (NBD) fluorophore using ethanol amine as a linker. Isomerization of the double bond at the side chain of abscisic acid happened during the synthesis. The resulting fluorophore analogues derived from both isomeric compounds entered cells suggesting a wide applicability of the ABA‐NBD conjugates as fluorescent probes to study ABA mechanism of action. The functional properties of the isomeric ABA‐NBD conjugates were tested in vitro, by measuring TNFα expression and nitrite concentration in LPS‐stimulated macrophages and compared with their non‐fluorescent ABA isomers. Rationalization of the results is given as supported by docking studies of the compounds with LANCL2 and PPARγ targets. [-]
Publicado en
ChemistrySelect, 2020, vol. 5, no 26Proyecto de investigación
Universitat Jaume I: UJIB2018-41, UJIB2018-01; Predoctoral Ministerio de Ciencia, Innovación y Universidades: FPU17/06209; Universitat Jaume I: PREDOC\2017\25Derechos de acceso
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